TY - JOUR
T1 - Gastrointestinal leiomyosarcoma metastatic to the liver. Durable tumor regression by hepatic chemoembolization infusion with cisplatin and vinblastine
AU - Mavligit, Giora M.
AU - Zukwiski, Alexander A.
AU - Ellis, Lee M.
AU - Chuang, Vincent P.
AU - Wallace, Sidney
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1995/4/15
Y1 - 1995/4/15
N2 - Background. Gastrointestinal leiomyosarcoma metastatic to the liver is considered most resistant to any combination of systemic chemotherapy containing doxorubicin and/or ifosphamide. Methods. Fourteen patients with gastrointestinal leiomyosarcoma metastatic to the liver were treated with hepatic chemoembolization infusion consisting of polyvinyl alcohol sponge particles mixed with cisplatin powder (150 mg) followed by an intrahepatic arterial infusion of vinblastine (10 mg/m2). Results. Ten major (>50% regression) tumor responses were observed (70%) in patients lasting from 8 to 31+ months (median, 12 months) after an average of two hepatic chemoembolization procedures, usually 4 weeks apart. Transient side effects included right upper quadrant pain requiring narcotics, significant hepatic enzyme elevation, particularly of lactic dehydrogenase with a minimal increase in bilirubin, paralytic ileus requiring nasogastric suction up to 72 hours, urinary electrolyte losses (potassium+, magnesium++, sodium+) requiring supplements, and occasionally mild but transient leukopenia and thrombocytopenia. Conclusions. Hepatic chemoembolization infusion appears to induce a high rate of durable tumor response in patients with notoriously chemoresistant gastrointestinal leiomyosarcoma metastatic to the liver.
AB - Background. Gastrointestinal leiomyosarcoma metastatic to the liver is considered most resistant to any combination of systemic chemotherapy containing doxorubicin and/or ifosphamide. Methods. Fourteen patients with gastrointestinal leiomyosarcoma metastatic to the liver were treated with hepatic chemoembolization infusion consisting of polyvinyl alcohol sponge particles mixed with cisplatin powder (150 mg) followed by an intrahepatic arterial infusion of vinblastine (10 mg/m2). Results. Ten major (>50% regression) tumor responses were observed (70%) in patients lasting from 8 to 31+ months (median, 12 months) after an average of two hepatic chemoembolization procedures, usually 4 weeks apart. Transient side effects included right upper quadrant pain requiring narcotics, significant hepatic enzyme elevation, particularly of lactic dehydrogenase with a minimal increase in bilirubin, paralytic ileus requiring nasogastric suction up to 72 hours, urinary electrolyte losses (potassium+, magnesium++, sodium+) requiring supplements, and occasionally mild but transient leukopenia and thrombocytopenia. Conclusions. Hepatic chemoembolization infusion appears to induce a high rate of durable tumor response in patients with notoriously chemoresistant gastrointestinal leiomyosarcoma metastatic to the liver.
KW - chemoembolization
KW - gastrointestinal leiomyosarcoma
KW - liver metastases cisplatin
KW - polyvinyl alcohol sponge particles
KW - vinblastine
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U2 - 10.1002/1097-0142(19950415)75:8<2083::AID-CNCR2820750809>3.0.CO;2-H
DO - 10.1002/1097-0142(19950415)75:8<2083::AID-CNCR2820750809>3.0.CO;2-H
M3 - Article
C2 - 7697597
AN - SCOPUS:0028958778
SN - 0008-543X
VL - 75
SP - 2083
EP - 2088
JO - Cancer
JF - Cancer
IS - 8
ER -