Gastrointestinal toxicities with combined antiangiogenic and stereotactic body radiation therapy

Erqi L. Pollom; Lei Deng; Reetesh K. Pai; J. Martin Brown; Amato Giaccia; Billy W. Loo; David B. Shultz; Quynh Thu Le; Albert C. Koong; Daniel T. Chang

doi:10.1016/j.ijrobp.2015.02.016

Gastrointestinal toxicities with combined antiangiogenic and stereotactic body radiation therapy

Erqi L. Pollom, Lei Deng, Reetesh K. Pai, J. Martin Brown, Amato Giaccia, Billy W. Loo, David B. Shultz, Quynh Thu Le, Albert C. Koong, Daniel T. Chang

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Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts.

Original language	English (US)
Pages (from-to)	568-576
Number of pages	9
Journal	International Journal of Radiation Oncology Biology Physics
Volume	92
Issue number	3
DOIs	https://doi.org/10.1016/j.ijrobp.2015.02.016
State	Published - Jan 1 2015

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Radiation
Cancer Research

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title = "Gastrointestinal toxicities with combined antiangiogenic and stereotactic body radiation therapy",

abstract = "Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts.",

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AU - Pollom, Erqi L.

AU - Deng, Lei

AU - Pai, Reetesh K.

AU - Brown, J. Martin

AU - Giaccia, Amato

AU - Loo, Billy W.

AU - Shultz, David B.

AU - Le, Quynh Thu

AU - Koong, Albert C.

AU - Chang, Daniel T.

PY - 2015/1/1

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N2 - Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts.

AB - Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts.

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Gastrointestinal toxicities with combined antiangiogenic and stereotactic body radiation therapy

Abstract

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