TY - JOUR
T1 - GATE Monte Carlo simulation of a high-sensitivity and high-resolution LSO-based small animal PET camera
AU - Baghaei, Hossain
AU - Zhang, Yuxuan
AU - Li, Hongdi
AU - Wang, Yu
AU - Kim, Soonseok
AU - Ramirez, Rocio A.
AU - Liu, Jiguo
AU - Liu, Shitao
AU - Wong, Wai Hoi
N1 - Funding Information:
Manuscript received January 22, 2007; revised April 23, 2007. This work was supported in part by the NIH under Grants RO1 CA58980, RO1 CA61880, RO1 CA76246, RO1 EB00217, RO1 EB001038, and in part by a U.S. Army Breast Cancer Grant, in part by a Texas Higher Education Grant, in part by a John S. Dunn Foundation Research Grant, and in part by the Cobb Foundation for Cancer Research.
PY - 2007/10
Y1 - 2007/10
N2 - In this paper, we describe a Monte Carlo simulation of the performance of a high-sensitivity and high-resolution small animal positron emission tomography (PET) scanner with a large axial field-of-view (AFOV). The simulated camera is based on the photomultiplier-quadrant-sharing (PQS) concept and composed of 180 blocks of 14 × 14 lutetium oxyorthosilicate (LSO) crystals each measuring 1.16 mm transaxially, 1.27 mm transaxially, and 9.4 mm radially. The camera has 84 detector rings with an 11.6 cm AFOV and a ring diameter of 16.6 cm. For the simulation, we used the Geant4 Application for Tomographic Emission (GATE) simulation package. We validated GATE by comparing its predictions for spatial resolution, absolute sensitivity, and count rate with measured data obtained using an existing bismuth germanate (BGO) based dedicated animal PET scanner that had a similar AFOV and ring diameter and was based on the PQS technique. Simulated and experimental images of the Data Spectrum Micro Deluxe phantom were also compared. The simulation data suggested that new LSO-based scanner could have reconstructed radial (tangential) spatial resolutions of 1.14 mm (1.14 mm), 1.31 mm (1.32 mm), 1.54 mm (1.52 mm), 2.01 mm (1.8 mm), and 2.4 mm (2.1 mm) at the center and 1 cm, 2 cm, 3 cm, and 4 cm off center, respectively. The simulation data also suggested that 1.2-mm hot rods in the Micro Deluxe phantom will be distinguishable. Simulation predicted an absolute sensitivity of about 7.3% for a point source at the center of the camera assuming an energy window of 300 keV to 750 keV, a coincidence time window of 8 ns, and a system dead time of 60 ns.
AB - In this paper, we describe a Monte Carlo simulation of the performance of a high-sensitivity and high-resolution small animal positron emission tomography (PET) scanner with a large axial field-of-view (AFOV). The simulated camera is based on the photomultiplier-quadrant-sharing (PQS) concept and composed of 180 blocks of 14 × 14 lutetium oxyorthosilicate (LSO) crystals each measuring 1.16 mm transaxially, 1.27 mm transaxially, and 9.4 mm radially. The camera has 84 detector rings with an 11.6 cm AFOV and a ring diameter of 16.6 cm. For the simulation, we used the Geant4 Application for Tomographic Emission (GATE) simulation package. We validated GATE by comparing its predictions for spatial resolution, absolute sensitivity, and count rate with measured data obtained using an existing bismuth germanate (BGO) based dedicated animal PET scanner that had a similar AFOV and ring diameter and was based on the PQS technique. Simulated and experimental images of the Data Spectrum Micro Deluxe phantom were also compared. The simulation data suggested that new LSO-based scanner could have reconstructed radial (tangential) spatial resolutions of 1.14 mm (1.14 mm), 1.31 mm (1.32 mm), 1.54 mm (1.52 mm), 2.01 mm (1.8 mm), and 2.4 mm (2.1 mm) at the center and 1 cm, 2 cm, 3 cm, and 4 cm off center, respectively. The simulation data also suggested that 1.2-mm hot rods in the Micro Deluxe phantom will be distinguishable. Simulation predicted an absolute sensitivity of about 7.3% for a point source at the center of the camera assuming an energy window of 300 keV to 750 keV, a coincidence time window of 8 ns, and a system dead time of 60 ns.
KW - GATE
KW - Geant4
KW - Monte Carlo simulations
KW - Positron emission tomography (PET)
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U2 - 10.1109/TNS.2007.905165
DO - 10.1109/TNS.2007.905165
M3 - Article
AN - SCOPUS:35348992262
SN - 0018-9499
VL - 54
SP - 1568
EP - 1573
JO - IEEE Transactions on Nuclear Science
JF - IEEE Transactions on Nuclear Science
IS - 5
ER -