GD2 and GD3 synthase: novel drug targets for cancer therapy

Nathalie Sphyris; Tapasree Roy Sarkar; Venkata L. Battula; Michael Andreeff; Sendurai A. Mani

doi:10.4161/23723556.2014.975068

GD2 and GD3 synthase: novel drug targets for cancer therapy

Nathalie Sphyris, Tapasree Roy Sarkar, Venkata L. Battula, Michael Andreeff, Sendurai A. Mani

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Our recent study suggests that targeting GD3 synthase (also known as ST8SIA1)—the rate-limiting enzyme in biosynthesis of the breast cancer stem cell marker GD2—abrogates metastasis and depletes the cancer stem cell populations within a tumor, thus providing an effective therapeutic strategy against metastatic breast cancers.

Original language	English (US)
Article number	e975068
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/23723556.2014.975068
State	Published - Jul 3 2015

Keywords

EMT
GD2
GD3S
cancer stem cells
metastasis

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723556.2014.975068

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title = "GD2 and GD3 synthase: novel drug targets for cancer therapy",

abstract = "Our recent study suggests that targeting GD3 synthase (also known as ST8SIA1)—the rate-limiting enzyme in biosynthesis of the breast cancer stem cell marker GD2—abrogates metastasis and depletes the cancer stem cell populations within a tumor, thus providing an effective therapeutic strategy against metastatic breast cancers.",

keywords = "EMT, GD2, GD3S, cancer stem cells, metastasis",

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AU - Sarkar, Tapasree Roy

AU - Battula, Venkata L.

AU - Andreeff, Michael

AU - Mani, Sendurai A.

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PY - 2015/7/3

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AB - Our recent study suggests that targeting GD3 synthase (also known as ST8SIA1)—the rate-limiting enzyme in biosynthesis of the breast cancer stem cell marker GD2—abrogates metastasis and depletes the cancer stem cell populations within a tumor, thus providing an effective therapeutic strategy against metastatic breast cancers.

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KW - metastasis

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GD2 and GD3 synthase: novel drug targets for cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

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