Gemcitabine: Actions and interactions

William Plunkett; Peng Huang; Varsha Gandhi

doi:10.1080/07328319708006168

Gemcitabine: Actions and interactions

William Plunkett, Peng Huang, Varsha Gandhi

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Abstract

Gemcitabine is a nucleoside analog that acts by multiple mechanisms. Incorporation of the triphosphate and subsequent inhibition of DNA replication and repair appears to be the major mode of action. Ribonucleotide reductase is inhibited by gemcitabine diphosphate, an activity that leads to metabolic self-potentiating effects.

Original language	English (US)
Pages (from-to)	1261-1270
Number of pages	10
Journal	Nucleosides and Nucleotides
Volume	16
Issue number	7-9
DOIs	https://doi.org/10.1080/07328319708006168
State	Published - 1997

ASJC Scopus subject areas

Biochemistry
Genetics

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10.1080/07328319708006168

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title = "Gemcitabine: Actions and interactions",

abstract = "Gemcitabine is a nucleoside analog that acts by multiple mechanisms. Incorporation of the triphosphate and subsequent inhibition of DNA replication and repair appears to be the major mode of action. Ribonucleotide reductase is inhibited by gemcitabine diphosphate, an activity that leads to metabolic self-potentiating effects.",

author = "William Plunkett and Peng Huang and Varsha Gandhi",

note = "Funding Information: The work from the authors' laboratories have been supported in part by grants CA28596, CA32839, CA55164, and CA57629 from the National Cancer Institute and by American Cancer Society grant DPH-1 .",

year = "1997",

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T2 - Actions and interactions

AU - Plunkett, William

AU - Huang, Peng

AU - Gandhi, Varsha

N1 - Funding Information: The work from the authors' laboratories have been supported in part by grants CA28596, CA32839, CA55164, and CA57629 from the National Cancer Institute and by American Cancer Society grant DPH-1 .

PY - 1997

Y1 - 1997

N2 - Gemcitabine is a nucleoside analog that acts by multiple mechanisms. Incorporation of the triphosphate and subsequent inhibition of DNA replication and repair appears to be the major mode of action. Ribonucleotide reductase is inhibited by gemcitabine diphosphate, an activity that leads to metabolic self-potentiating effects.

AB - Gemcitabine is a nucleoside analog that acts by multiple mechanisms. Incorporation of the triphosphate and subsequent inhibition of DNA replication and repair appears to be the major mode of action. Ribonucleotide reductase is inhibited by gemcitabine diphosphate, an activity that leads to metabolic self-potentiating effects.

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Gemcitabine: Actions and interactions

Abstract

ASJC Scopus subject areas

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