Gender differences in affective response to acute nicotine administration and deprivation

Jason D. Robinson; Paul M. Cinciripini; Stephen T. Tiffany; Brian L. Carter; Cho Y. Lam; David W. Wetter

doi:10.1016/j.addbeh.2006.05.021

Gender differences in affective response to acute nicotine administration and deprivation

Jason D. Robinson, Paul M. Cinciripini, Stephen T. Tiffany, Brian L. Carter, Cho Y. Lam, David W. Wetter

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Men and women may differ in their sensitivity to the mood-modulating properties of nicotine. Male and female adult smokers were exposed to four sessions crossing two nicotine deprivation conditions (12-h deprived vs. nondeprived) with two drug conditions (nicotine vs. placebo nasal spray). Acoustic probes elicited startle eyeblink responses while viewing affective and cigarette-related slides. In-session mood ratings were collected to gauge self-reported negative affect, positive affect, and craving. Nicotine nasal spray reduced startle amplitude in both men and women following 12-h deprivation compared with smoking nondeprivation. During nondeprivation, nicotine nasal spray increased startle amplitude in women compared with placebo spray, whereas no difference was found for men. The startle results suggest that both men and women are responsive to the hedonic properties of nicotine.

Original language	English (US)
Pages (from-to)	543-561
Number of pages	19
Journal	Addictive Behaviors
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.addbeh.2006.05.021
State	Published - Mar 2007

Keywords

Affect
Gender differences
Nicotine
Smoking deprivation
Startle

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Psychology
Toxicology
Psychiatry and Mental health

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10.1016/j.addbeh.2006.05.021

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title = "Gender differences in affective response to acute nicotine administration and deprivation",

abstract = "Men and women may differ in their sensitivity to the mood-modulating properties of nicotine. Male and female adult smokers were exposed to four sessions crossing two nicotine deprivation conditions (12-h deprived vs. nondeprived) with two drug conditions (nicotine vs. placebo nasal spray). Acoustic probes elicited startle eyeblink responses while viewing affective and cigarette-related slides. In-session mood ratings were collected to gauge self-reported negative affect, positive affect, and craving. Nicotine nasal spray reduced startle amplitude in both men and women following 12-h deprivation compared with smoking nondeprivation. During nondeprivation, nicotine nasal spray increased startle amplitude in women compared with placebo spray, whereas no difference was found for men. The startle results suggest that both men and women are responsive to the hedonic properties of nicotine.",

keywords = "Affect, Gender differences, Nicotine, Smoking deprivation, Startle",

author = "Robinson, {Jason D.} and Cinciripini, {Paul M.} and Tiffany, {Stephen T.} and Carter, {Brian L.} and Lam, {Cho Y.} and Wetter, {David W.}",

note = "Funding Information: Supported by grants from the Texas Tobacco Settlement, the National Cancer Institute (1R21CA81649) and the National Institute on Drug Abuse (R01DA1182-01) to Dr. Cinciripini, and a M. D. Anderson Education Program in Cancer Prevention Postdoctoral Fellowship Grant (R25CA57730) to Dr. Robinson. Pharmacia and Upjohn, Inc. provided the nicotine and placebo nasal spray. We thank Drs. Terry Blumenthal and Margaret Bradley for their technical assistance and Dr. Tracy Long, Cathy Sanders, Renata Benjamin, and Deena Martinez for their assistance in data collection.",

year = "2007",

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doi = "10.1016/j.addbeh.2006.05.021",

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AU - Wetter, David W.

N1 - Funding Information: Supported by grants from the Texas Tobacco Settlement, the National Cancer Institute (1R21CA81649) and the National Institute on Drug Abuse (R01DA1182-01) to Dr. Cinciripini, and a M. D. Anderson Education Program in Cancer Prevention Postdoctoral Fellowship Grant (R25CA57730) to Dr. Robinson. Pharmacia and Upjohn, Inc. provided the nicotine and placebo nasal spray. We thank Drs. Terry Blumenthal and Margaret Bradley for their technical assistance and Dr. Tracy Long, Cathy Sanders, Renata Benjamin, and Deena Martinez for their assistance in data collection.

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N2 - Men and women may differ in their sensitivity to the mood-modulating properties of nicotine. Male and female adult smokers were exposed to four sessions crossing two nicotine deprivation conditions (12-h deprived vs. nondeprived) with two drug conditions (nicotine vs. placebo nasal spray). Acoustic probes elicited startle eyeblink responses while viewing affective and cigarette-related slides. In-session mood ratings were collected to gauge self-reported negative affect, positive affect, and craving. Nicotine nasal spray reduced startle amplitude in both men and women following 12-h deprivation compared with smoking nondeprivation. During nondeprivation, nicotine nasal spray increased startle amplitude in women compared with placebo spray, whereas no difference was found for men. The startle results suggest that both men and women are responsive to the hedonic properties of nicotine.

AB - Men and women may differ in their sensitivity to the mood-modulating properties of nicotine. Male and female adult smokers were exposed to four sessions crossing two nicotine deprivation conditions (12-h deprived vs. nondeprived) with two drug conditions (nicotine vs. placebo nasal spray). Acoustic probes elicited startle eyeblink responses while viewing affective and cigarette-related slides. In-session mood ratings were collected to gauge self-reported negative affect, positive affect, and craving. Nicotine nasal spray reduced startle amplitude in both men and women following 12-h deprivation compared with smoking nondeprivation. During nondeprivation, nicotine nasal spray increased startle amplitude in women compared with placebo spray, whereas no difference was found for men. The startle results suggest that both men and women are responsive to the hedonic properties of nicotine.

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Gender differences in affective response to acute nicotine administration and deprivation

Abstract

Keywords

ASJC Scopus subject areas

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