Abstract
Lung cancer represents a paradigm for carcinogen-induced cancers. Tobacco smoke has over 100 carcinogenic agents and the specific interactions of specific carcinogens with genes that suppress tumors and repair DNA have been identified [1]. Lung cancers show multiple genetic lesions and these can be detected even in histologically normal bronchial mucosa from individuals with a smoking history. These genetic abnormalities provide an array of targets for therapy. The p53 tumor suppressor gene appears to play a central role in lung cancer development and was the initial focus of gene therapy approaches to lung cancer.
Original language | English (US) |
---|---|
Title of host publication | Tumors of the Chest |
Subtitle of host publication | Biology, Diagnosis and Management |
Publisher | Springer Berlin Heidelberg |
Pages | 431-438 |
Number of pages | 8 |
ISBN (Print) | 6293603618, 9783540310396 |
DOIs | |
State | Published - 2006 |
ASJC Scopus subject areas
- General Medicine