Gene therapy for the treatment of lung cancer

As the knowledge of the molecular and genetic mechanisms of oncogenesis has increased exponentially in recent years, the focus of cancer treatment has shifted to the molecular level. During their life span, cancer cells acquire genetic and molecular alterations allowing them to survive, proliferate, invade, metastasize, and become resistant to therapy. Due to their vital role, such molecular and genetic acquisitions are ideal targets for therapeutic strategies in the fight against cancer. This targeted strategy has been implemented in the development of gene-based therapies with the goal of replacing or correcting mutations or to incorporate new or loss encoding for absent proteins.