Genetic abnormalities in oligodendroglial and ependymal tumours

Ann C. Goussia; Athanassios P. Kyritsis; Paraskevi Mitlianga; Janet M. Bruner

doi:10.1007/s004150170021

Genetic abnormalities in oligodendroglial and ependymal tumours

Ann C. Goussia, Athanassios P. Kyritsis, Paraskevi Mitlianga, Janet M. Bruner

Pathology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Oligodendroglial and ependymal tumours are not the most common glial neoplasms; however, they are important subtypes of gliomas with different tumour biologies. Cytogenetic information has suggested that losses of chromosomes 1 p and 19 q are the most frequent genetic alterations in oligodendroglial tumours. Combined loss of these chromosomes has been associated with better chemotherapeutic response and prolonged overall survival. Loss of chromosome 22 is a well defined abnormality in ependymomas. In addition, deletion of chromosome 6 q may be another frequent chromosomic aberration in paediatric ependymomas.

Original language	English (US)
Pages (from-to)	1030-1035
Number of pages	6
Journal	Journal of Neurology
Volume	248
Issue number	12
DOIs	https://doi.org/10.1007/s004150170021
State	Published - 2001

Keywords

Brain neoplasms
Ependymomas
Molecular biology
Oligodendrogliomas

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1007/s004150170021

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title = "Genetic abnormalities in oligodendroglial and ependymal tumours",

abstract = "Oligodendroglial and ependymal tumours are not the most common glial neoplasms; however, they are important subtypes of gliomas with different tumour biologies. Cytogenetic information has suggested that losses of chromosomes 1 p and 19 q are the most frequent genetic alterations in oligodendroglial tumours. Combined loss of these chromosomes has been associated with better chemotherapeutic response and prolonged overall survival. Loss of chromosome 22 is a well defined abnormality in ependymomas. In addition, deletion of chromosome 6 q may be another frequent chromosomic aberration in paediatric ependymomas.",

keywords = "Brain neoplasms, Ependymomas, Molecular biology, Oligodendrogliomas",

author = "Goussia, {Ann C.} and Kyritsis, {Athanassios P.} and Paraskevi Mitlianga and Bruner, {Janet M.}",

year = "2001",

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T1 - Genetic abnormalities in oligodendroglial and ependymal tumours

AU - Goussia, Ann C.

AU - Kyritsis, Athanassios P.

AU - Mitlianga, Paraskevi

AU - Bruner, Janet M.

PY - 2001

Y1 - 2001

N2 - Oligodendroglial and ependymal tumours are not the most common glial neoplasms; however, they are important subtypes of gliomas with different tumour biologies. Cytogenetic information has suggested that losses of chromosomes 1 p and 19 q are the most frequent genetic alterations in oligodendroglial tumours. Combined loss of these chromosomes has been associated with better chemotherapeutic response and prolonged overall survival. Loss of chromosome 22 is a well defined abnormality in ependymomas. In addition, deletion of chromosome 6 q may be another frequent chromosomic aberration in paediatric ependymomas.

AB - Oligodendroglial and ependymal tumours are not the most common glial neoplasms; however, they are important subtypes of gliomas with different tumour biologies. Cytogenetic information has suggested that losses of chromosomes 1 p and 19 q are the most frequent genetic alterations in oligodendroglial tumours. Combined loss of these chromosomes has been associated with better chemotherapeutic response and prolonged overall survival. Loss of chromosome 22 is a well defined abnormality in ependymomas. In addition, deletion of chromosome 6 q may be another frequent chromosomic aberration in paediatric ependymomas.

KW - Brain neoplasms

KW - Ependymomas

KW - Molecular biology

KW - Oligodendrogliomas

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JO - Journal of Neurology

JF - Journal of Neurology

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ER -

Genetic abnormalities in oligodendroglial and ependymal tumours

Abstract

Keywords

ASJC Scopus subject areas

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