Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer

Donghui Li; Farzana L. Walcott; Ping Chang; Weiqing Zhang; Jijiang Zhu; Elaine Petrulis; Sonja E. Singletary; Aysegul A. Sahin; Melissa L. Bondy

Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer

Donghui Li, Farzana L. Walcott, Ping Chang, Weiqing Zhang, Jijiang Zhu, Elaine Petrulis, Sonja E. Singletary, Aysegul A. Sahin, Melissa L. Bondy

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29 Scopus citations

Abstract

To test the hypothesis that individual susceptibility to carcinogen exposure is a risk factor for breast cancer, we measured DNA adduct formation in normal breast tissues treated in vitro with 4 μm benzo(a)pyrene in 76 cancer cases and 60 noncancer controls. We found a significantly higher level of adducts (134.6 ± 21.2/10⁹) among cases compared with controls (66.9 ± 7.5; P = 0.007). The level of adducts was significantly associated with the risk of breast cancer (odds ratio, 4.38; 95% confidence interval, 1.04 to 18.50; P = 0.044) after adjusting for confounders. Stratified analysis and regression analysis demonstrated that race, pack-years of smoking, family history of breast cancer, and CYP1B1 genotype were significant predictors of the level of benzo(a)pyrene-induced adducts in the breast tissues. These observations suggest that genetic susceptibility to carcinogen exposure may play an important role in breast carcinogenesis.

Original language	English (US)
Pages (from-to)	4566-4570
Number of pages	5
Journal	Cancer Research
Volume	62
Issue number	16
State	Published - Aug 15 2002

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer",

abstract = "To test the hypothesis that individual susceptibility to carcinogen exposure is a risk factor for breast cancer, we measured DNA adduct formation in normal breast tissues treated in vitro with 4 μm benzo(a)pyrene in 76 cancer cases and 60 noncancer controls. We found a significantly higher level of adducts (134.6 ± 21.2/109) among cases compared with controls (66.9 ± 7.5; P = 0.007). The level of adducts was significantly associated with the risk of breast cancer (odds ratio, 4.38; 95% confidence interval, 1.04 to 18.50; P = 0.044) after adjusting for confounders. Stratified analysis and regression analysis demonstrated that race, pack-years of smoking, family history of breast cancer, and CYP1B1 genotype were significant predictors of the level of benzo(a)pyrene-induced adducts in the breast tissues. These observations suggest that genetic susceptibility to carcinogen exposure may play an important role in breast carcinogenesis.",

author = "Donghui Li and Walcott, {Farzana L.} and Ping Chang and Weiqing Zhang and Jijiang Zhu and Elaine Petrulis and Singletary, {Sonja E.} and Sahin, {Aysegul A.} and Bondy, {Melissa L.}",

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AU - Li, Donghui

AU - Walcott, Farzana L.

AU - Chang, Ping

AU - Zhang, Weiqing

AU - Zhu, Jijiang

AU - Petrulis, Elaine

AU - Singletary, Sonja E.

AU - Sahin, Aysegul A.

AU - Bondy, Melissa L.

PY - 2002/8/15

Y1 - 2002/8/15

N2 - To test the hypothesis that individual susceptibility to carcinogen exposure is a risk factor for breast cancer, we measured DNA adduct formation in normal breast tissues treated in vitro with 4 μm benzo(a)pyrene in 76 cancer cases and 60 noncancer controls. We found a significantly higher level of adducts (134.6 ± 21.2/109) among cases compared with controls (66.9 ± 7.5; P = 0.007). The level of adducts was significantly associated with the risk of breast cancer (odds ratio, 4.38; 95% confidence interval, 1.04 to 18.50; P = 0.044) after adjusting for confounders. Stratified analysis and regression analysis demonstrated that race, pack-years of smoking, family history of breast cancer, and CYP1B1 genotype were significant predictors of the level of benzo(a)pyrene-induced adducts in the breast tissues. These observations suggest that genetic susceptibility to carcinogen exposure may play an important role in breast carcinogenesis.

AB - To test the hypothesis that individual susceptibility to carcinogen exposure is a risk factor for breast cancer, we measured DNA adduct formation in normal breast tissues treated in vitro with 4 μm benzo(a)pyrene in 76 cancer cases and 60 noncancer controls. We found a significantly higher level of adducts (134.6 ± 21.2/109) among cases compared with controls (66.9 ± 7.5; P = 0.007). The level of adducts was significantly associated with the risk of breast cancer (odds ratio, 4.38; 95% confidence interval, 1.04 to 18.50; P = 0.044) after adjusting for confounders. Stratified analysis and regression analysis demonstrated that race, pack-years of smoking, family history of breast cancer, and CYP1B1 genotype were significant predictors of the level of benzo(a)pyrene-induced adducts in the breast tissues. These observations suggest that genetic susceptibility to carcinogen exposure may play an important role in breast carcinogenesis.

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SN - 0008-5472

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JO - Cancer Research

JF - Cancer Research

IS - 16

ER -

Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer

Abstract

ASJC Scopus subject areas

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