Genetic and molecular characterization of uveal melanoma cell lines

K. G. Griewank; X. Yu; J. Khalili; M. M. Sozen; K. Stempke-Hale; C. Bernatchez; S. Wardell; B. C. Bastian; S. E. Woodman

doi:10.1111/j.1755-148X.2012.00971.x

Genetic and molecular characterization of uveal melanoma cell lines

K. G. Griewank, X. Yu, J. Khalili, M. M. Sozen, K. Stempke-Hale, C. Bernatchez, S. Wardell, B. C. Bastian, S. E. Woodman

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community. Published 2012. This article is a US Government work and is in the public domain in the USA.

Original language	English (US)
Pages (from-to)	182-187
Number of pages	6
Journal	Pigment Cell and Melanoma Research
Volume	25
Issue number	2
DOIs	https://doi.org/10.1111/j.1755-148X.2012.00971.x
State	Published - Mar 2012

Keywords

GNA11
GNAQ
Uveal melanoma

ASJC Scopus subject areas

Oncology
General Biochemistry, Genetics and Molecular Biology
Dermatology

MD Anderson CCSG core facilities

Advanced Technology Genomics Core
Cytogenetics and Cell Authentication Core

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10.1111/j.1755-148X.2012.00971.x

Cite this

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title = "Genetic and molecular characterization of uveal melanoma cell lines",

abstract = "The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community. Published 2012. This article is a US Government work and is in the public domain in the USA.",

keywords = "GNA11, GNAQ, Uveal melanoma",

author = "Griewank, {K. G.} and X. Yu and J. Khalili and Sozen, {M. M.} and K. Stempke-Hale and C. Bernatchez and S. Wardell and Bastian, {B. C.} and Woodman, {S. E.}",

year = "2012",

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language = "English (US)",

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TY - JOUR

T1 - Genetic and molecular characterization of uveal melanoma cell lines

AU - Griewank, K. G.

AU - Yu, X.

AU - Khalili, J.

AU - Sozen, M. M.

AU - Stempke-Hale, K.

AU - Bernatchez, C.

AU - Wardell, S.

AU - Bastian, B. C.

AU - Woodman, S. E.

PY - 2012/3

Y1 - 2012/3

N2 - The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community. Published 2012. This article is a US Government work and is in the public domain in the USA.

AB - The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal melanoma provides an opportunity to better understand the pathogenesis of this melanoma subtype and to develop rational therapeutics to target the cellular effects mediated by these mutations. Cell lines from uveal melanoma tumors are an essential tool for these types of analyses. We report the mutation status of relevant melanoma genes, expression levels of proteins of interest, and DNA fingerprinting of a panel of uveal melanoma cell lines used in the research community. Published 2012. This article is a US Government work and is in the public domain in the USA.

KW - GNA11

KW - GNAQ

KW - Uveal melanoma

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Genetic and molecular characterization of uveal melanoma cell lines

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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