Abstract
The author reviews current findings regarding inherited cancer predisposition and childhood cancer and proposes development of genetic services for long‐term survivors of childhood cancer. Overall, it is suggested that relatively rare germline mutations in the tumor suppressor genes, Rb, p53, and WT1, may have important implications for long‐term survivors relevant to familial cancer, second malignant neoplasms, and developmental disorders. Although continued research clearly is needed, planning for genetic services for long‐term survivors should begin now.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3435-3440 |
| Number of pages | 6 |
| Journal | Cancer |
| Volume | 71 |
| Issue number | 10 S |
| DOIs | |
| State | Published - May 15 1993 |
Keywords
- Wilms tumor
- genetics
- long‐term survivor
- osteosarcoma
- retinoblastoma
- second malignant neoplasm
- soft tissue sarcoma
ASJC Scopus subject areas
- Oncology
- Cancer Research