Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

Natalia Soshnikova; Dietmar Zechner; Joerg Huelsken; Yuji Mishina; Richard R. Behringer; Makoto M. Taketo; E. Bryan Crenshaw; Walter Birchmeier

doi:10.1101/gad.263003

Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

Natalia Soshnikova, Dietmar Zechner, Joerg Huelsken, Yuji Mishina, Richard R. Behringer, Makoto M. Taketo, E. Bryan Crenshaw, Walter Birchmeier

Genetics

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that β-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/β-catenin and BMP receptor signaling.

Original language	English (US)
Pages (from-to)	1963-1968
Number of pages	6
Journal	Genes and Development
Volume	17
Issue number	16
DOIs	https://doi.org/10.1101/gad.263003
State	Published - Aug 15 2003

Keywords

Engrailed-1
FGF
Frizzled
Limb ventral ectoderm
Proximal-distal axis

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.263003

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abstract = "By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that β-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/β-catenin and BMP receptor signaling.",

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T1 - Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

AU - Soshnikova, Natalia

AU - Zechner, Dietmar

AU - Huelsken, Joerg

AU - Mishina, Yuji

AU - Behringer, Richard R.

AU - Taketo, Makoto M.

AU - Crenshaw, E. Bryan

AU - Birchmeier, Walter

PY - 2003/8/15

Y1 - 2003/8/15

N2 - By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that β-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/β-catenin and BMP receptor signaling.

AB - By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that β-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/β-catenin and BMP receptor signaling.

KW - Engrailed-1

KW - FGF

KW - Frizzled

KW - Limb ventral ectoderm

KW - Proximal-distal axis

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Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

Abstract

Keywords

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