Genetic mosaicism in normal tissues of Wilms' tumour patients

Lian Yu Chao; Vicki Huff; Gail Tomlinson; Vincent M. Riccardi; Louise C. Strong; Grady F. Saunders

doi:10.1038/ng0293-127

Genetic mosaicism in normal tissues of Wilms' tumour patients

Lian Yu Chao, Vicki Huff, Gail Tomlinson, Vincent M. Riccardi, Louise C. Strong, Grady F. Saunders

Genetics

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

We describe the partial loss of heterozygosity (LOH) at chromosome 11 p loci in normal tissues (normal kidney and/or blood) from four of 67 Wilms' tumour patients. Autologous tumour DNA showed complete loss of the same, maternally derived, alleles. These observations indicate that the normal tissues were mosaic for cells heterozygous and homozygous for 11 p markers and that tumours subsequently developed from the homozygous cells that had undergone an 11 p somatic recombination event. We suggest that LOH for 11 p alleles is compatible with normal growth and differentiation and is significant pathologically only when accompanied by other genetic alterations.

Original language	English (US)
Pages (from-to)	127-131
Number of pages	5
Journal	Nature Genetics
Volume	3
Issue number	2
DOIs	https://doi.org/10.1038/ng0293-127
State	Published - Feb 1993

ASJC Scopus subject areas

Genetics

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AU - Chao, Lian Yu

AU - Huff, Vicki

AU - Tomlinson, Gail

AU - Riccardi, Vincent M.

AU - Strong, Louise C.

AU - Saunders, Grady F.

PY - 1993/2

Y1 - 1993/2

N2 - We describe the partial loss of heterozygosity (LOH) at chromosome 11 p loci in normal tissues (normal kidney and/or blood) from four of 67 Wilms' tumour patients. Autologous tumour DNA showed complete loss of the same, maternally derived, alleles. These observations indicate that the normal tissues were mosaic for cells heterozygous and homozygous for 11 p markers and that tumours subsequently developed from the homozygous cells that had undergone an 11 p somatic recombination event. We suggest that LOH for 11 p alleles is compatible with normal growth and differentiation and is significant pathologically only when accompanied by other genetic alterations.

AB - We describe the partial loss of heterozygosity (LOH) at chromosome 11 p loci in normal tissues (normal kidney and/or blood) from four of 67 Wilms' tumour patients. Autologous tumour DNA showed complete loss of the same, maternally derived, alleles. These observations indicate that the normal tissues were mosaic for cells heterozygous and homozygous for 11 p markers and that tumours subsequently developed from the homozygous cells that had undergone an 11 p somatic recombination event. We suggest that LOH for 11 p alleles is compatible with normal growth and differentiation and is significant pathologically only when accompanied by other genetic alterations.

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Genetic mosaicism in normal tissues of Wilms' tumour patients

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