TY - JOUR
T1 - Genetic polymorphisms and HPV infection in oral squamous cell carcinomas
AU - Sun, Yan
AU - Zhang, Yang
AU - Liu, Limei
AU - Song, Xicheng
AU - Li, Guojun
N1 - Publisher Copyright:
© Elsevier B.V. All rights reserved.
PY - 2015/6/8
Y1 - 2015/6/8
N2 - Despite declining smoking rates in the United States, the incidence of oral squamous cell carcinomas (OSCC, including oral cavity and oropharynx) is rising in young adults. The reasons have been attributed to changes in sexual behaviors and the increasingly prevalent infection of oncogenic subtypes of human papillomavirus (HPV), principally type16 and occasionally type18. However, only small proportion of individuals who have contracted HPV infection will develop OSCC, suggesting that there is an inter-individual variation in susceptibility to HPV infection and related OSCC. Identification of susceptible biomarkers for HPV status would be useful to identify those individuals who are susceptible to HPV infection, to refine the prognostication of HPV associated OSCC, and ultimately to improve prevention efforts for OSCC and potentially other HPV-associated diseases. Our public health OSCC prevention paradigm will need to expand beyond tobacco and alcohol control.
AB - Despite declining smoking rates in the United States, the incidence of oral squamous cell carcinomas (OSCC, including oral cavity and oropharynx) is rising in young adults. The reasons have been attributed to changes in sexual behaviors and the increasingly prevalent infection of oncogenic subtypes of human papillomavirus (HPV), principally type16 and occasionally type18. However, only small proportion of individuals who have contracted HPV infection will develop OSCC, suggesting that there is an inter-individual variation in susceptibility to HPV infection and related OSCC. Identification of susceptible biomarkers for HPV status would be useful to identify those individuals who are susceptible to HPV infection, to refine the prognostication of HPV associated OSCC, and ultimately to improve prevention efforts for OSCC and potentially other HPV-associated diseases. Our public health OSCC prevention paradigm will need to expand beyond tobacco and alcohol control.
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U2 - 10.1016/j.coviro.2015.05.004
DO - 10.1016/j.coviro.2015.05.004
M3 - Review article
C2 - 26057719
AN - SCOPUS:84930621651
SN - 1879-6257
VL - 14
SP - 1
EP - 6
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -