Genetic predisposition in gynecologic cancers

Molly S. Daniels; Karen H. Lu

doi:10.1053/j.seminoncol.2016.08.005

Genetic predisposition in gynecologic cancers

Molly S. Daniels, Karen H. Lu

Gynecological Oncology & Reproductive Medicine

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk-reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome. Individuals with Lynch syndrome should undergo screening colonoscopy every 1–2 years. Lynch syndrome causes a high risk of endometrial cancer, and women with Lynch syndrome should consult with a gynecologic specialist to formulate a plan for managing this risk.

Original language	English (US)
Pages (from-to)	543-547
Number of pages	5
Journal	Seminars in oncology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1053/j.seminoncol.2016.08.005
State	Published - Oct 1 2016

Keywords

BRCA1/2
Endometrial cancer
Hereditary cancer
Lynch syndrome
Ovarian cancer

ASJC Scopus subject areas

Hematology
Oncology

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10.1053/j.seminoncol.2016.08.005

Cite this

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title = "Genetic predisposition in gynecologic cancers",

abstract = "This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk-reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome. Individuals with Lynch syndrome should undergo screening colonoscopy every 1–2 years. Lynch syndrome causes a high risk of endometrial cancer, and women with Lynch syndrome should consult with a gynecologic specialist to formulate a plan for managing this risk.",

keywords = "BRCA1/2, Endometrial cancer, Hereditary cancer, Lynch syndrome, Ovarian cancer",

author = "Daniels, {Molly S.} and Lu, {Karen H.}",

note = "Funding Information: Supported by the NIH/NCI Clinical Cancer Support Grant under award number P30CA016672. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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AB - This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk-reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome. Individuals with Lynch syndrome should undergo screening colonoscopy every 1–2 years. Lynch syndrome causes a high risk of endometrial cancer, and women with Lynch syndrome should consult with a gynecologic specialist to formulate a plan for managing this risk.

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KW - Ovarian cancer

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Genetic predisposition in gynecologic cancers

Abstract

Keywords

ASJC Scopus subject areas

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