TY - JOUR
T1 - Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma
AU - Li, Chunying
AU - Liu, Zhensheng
AU - Zhang, Zhengdong
AU - Strom, Sara S.
AU - Gershenwald, Jeffrey E.
AU - Prieto, Victor G.
AU - Lee, Jeffrey E.
AU - Ross, Merrick I.
AU - Mansfield, Paul F.
AU - Cormier, Janice N.
AU - Duvic, Madeleine
AU - Grimm, Elizabeth A.
AU - Wei, Qingyi
N1 - Funding Information:
We thank Margaret Lung for assistance in recruiting the subjects; Derek Larson, Zhaozheng Guo, Yawei Qiao, Jianzhong He, and Kejing Xu for laboratory assistance; Li-E Wang for technical support; Monica Domingue for assistance in preparing the manuscript; and Pierrette Lo for scientific editing. This study was supported by the National Institutes of Health, National Cancer Institute Grants R01 CA 100264 (Q.W.) and P50 CA 093459 (E.A.G.), and in part by the National Institute of Environmental Health Sciences Grants R01 ES11740 (Q.W.) and P30 CA16672 (M.D. Anderson Cancer Center).
PY - 2007/2
Y1 - 2007/2
N2 - Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). We hypothesized that genetic polymorphisms of VDR are associated with risk of CM. In a hospital-based case-control study of 602 non-Hispanic white CM patients and 603 cancer-free control subjects frequency matched by age and sex, we genotyped two VDR polymorphisms (TaqI and FokI) and assessed their association with CM risk. We found that a significantly decreased risk was associated with VDR-TaqI Tt (adjusted odds ratio (OR), 0.70; 95% confidence interval (CI), 0.54-0.90) and Tt + tt (OR=0.70; 95% CI, 0.55-0.89) genotypes, compared with the VDR-TaqI TT genotype, whereas an increased risk was associated with VDR-FokI Ff genotype (OR=1.32; 95% CI, 1.03-1.68), and a borderline significantly increased risk was associated with Ff + ff (OR=1.26; 95% CI, 1.00-1.59) genotypes, compared with the VDR-FokI FF genotype. In conclusion, genetic variants (i.e., TaqI t protective allele and FokI f risk allele) in VDR may alter risk of CM.
AB - Sunlight causes DNA damage but also induces production of vitamin D whose metabolite 1,25-(OH)2D3 has antiproliferative and pro-differentiative effects in both melanocytes and cutaneous melanoma (CM) cells mediated through the vitamin D receptor (VDR). We hypothesized that genetic polymorphisms of VDR are associated with risk of CM. In a hospital-based case-control study of 602 non-Hispanic white CM patients and 603 cancer-free control subjects frequency matched by age and sex, we genotyped two VDR polymorphisms (TaqI and FokI) and assessed their association with CM risk. We found that a significantly decreased risk was associated with VDR-TaqI Tt (adjusted odds ratio (OR), 0.70; 95% confidence interval (CI), 0.54-0.90) and Tt + tt (OR=0.70; 95% CI, 0.55-0.89) genotypes, compared with the VDR-TaqI TT genotype, whereas an increased risk was associated with VDR-FokI Ff genotype (OR=1.32; 95% CI, 1.03-1.68), and a borderline significantly increased risk was associated with Ff + ff (OR=1.26; 95% CI, 1.00-1.59) genotypes, compared with the VDR-FokI FF genotype. In conclusion, genetic variants (i.e., TaqI t protective allele and FokI f risk allele) in VDR may alter risk of CM.
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U2 - 10.1038/sj.jid.5700544
DO - 10.1038/sj.jid.5700544
M3 - Article
C2 - 16990805
AN - SCOPUS:33846206885
SN - 0022-202X
VL - 127
SP - 276
EP - 280
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 2
ER -