@article{9949aac004164b4fb28d6cf9229766c0,
title = "Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate",
abstract = "By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex-A nd age-related expression patterns. Findings include a master regulatory locus that likely has a role in immune function and a locus regulating hippocampal long noncoding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.",
author = "Jasinska, {Anna J.} and Ivette Zelaya and Service, {Susan K.} and Peterson, {Christine B.} and Cantor, {Rita M.} and Choi, {Oi Wa} and Joseph DeYoung and Eleazar Eskin and Fairbanks, {Lynn A.} and Scott Fears and Furterer, {Allison E.} and Huang, {Yu S.} and Vasily Ramensky and Schmitt, {Christopher A.} and Hannes Svardal and Jorgensen, {Matthew J.} and Kaplan, {Jay R.} and Diego Villar and Aken, {Bronwen L.} and Paul Flicek and Rishi Nag and Wong, {Emily S.} and John Blangero and Dyer, {Thomas D.} and Marina Bogomolov and Yoav Benjamini and Weinstock, {George M.} and Ken Dewar and Chiara Sabatti and Wilson, {Richard K.} and Jentsch, {David J.} and Wesley Warren and Giovanni Coppola and Woods, {Roger P.} and Freimer, {Nelson B.}",
note = "Funding Information: We thank S. Groman for assistance with tissue resources; T. Chavanne, K. Finnie, M. Long, J. Gardin and D. Swaim for technical assistance with necropsies and tissue collections; and M. Vermunt for sharing rhesus macaque epigenetic data. This work was supported by the following grants, all from the US National Institutes of Health: U54HG00307907 (to R.K.W.); P40RR019963/OD010965 (to J.R.K.); R01RR016300/OD010980 (to N.B.F.); R37MH060233 (to D. Geschwind); UL1DE019580 (to R. Bilder); PL1NS062410 (to C. Evans); RL1MH083270 (to J.D.J.); P30NS062691 (to N.B.F. and G.C.); and R01MH101782 (to C.S. and E.E.). R.N., B.L.A. and P.F. acknowledge support from the Wellcome Trust. P.F., B.L.A. and R.N. acknowledge support from the Wellcome Trust (grant WT108749/Z/ 15/Z) and the European Molecular Biology Laboratory. E.S.W. was supported by an EMBO Advanced Fellowship (aALTF1672-2014). A.E.F. was supported by US National Institutes of Health award T32MH073526. Data were generated as part of the CommonMind Consortium supported by funding from Takeda Pharmaceuticals Company, F. Hoffman-La Roche and US National Institutes of Health grants R01MH085542, R01MH093725, P50MH066392, P50MH080405, R01MH097276, RO1MH-075916, P50M096891, P50MH084053S1, R37MH057881 and R37MH057881S1, HHSN271201300031C, AG02219, AG05138 and MH06692. Brain tissue for the study was obtained from the following brain bank collections: the Mount Sinai NIH Brain and Tissue Repository, the University of Pennsylvania Alzheimer{\textquoteright}s Disease Core Center, the University of Pittsburgh NeuroBioBank and Brain and Tissue Repositories, and the National Institute of Mental Health (NIMH) Human Brain Collection Core. CMC Leadership: P. Sklar, J. Buxbaum (Icahn School of Medicine at Mount Sinai), B. Devlin, D. Lewis (University of Pittsburgh), R. Gur, C.-G. Hahn (University of Pennsylvania), K. Hirai, H. Toyoshiba (Takeda Pharmaceuticals Company), E. Domenici, L. Essioux (F. Hoffman-La Roche), L. Mangravite, M. Peters (Sage Bionetworks), T. Lehner, B. Lipska (NIMH).",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/ng.3959",
language = "English (US)",
volume = "49",
pages = "1714--1721",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "12",
}