TY - JOUR
T1 - Genetically haploid spermatids are phenotypically diploid
AU - Braun, Robert E.
AU - Behringer, Richard R.
AU - Peschon, Jacques J.
AU - Brinster, Ralph L.
AU - Palmiter, Richard D.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - Because chromosomal homologues segregate from one another during meiosis, spermatids are genetically different. Post-meiotic gene expression could lead to gametic differences, some of which might lead to preferential transmission of certain alleles over others. In both insects and mammals, however, all the cells derived from a single spermatogonial cell develop within a common syncytium formed as a result of incomplete cytokinesis at each of the mitotic and meiotic cell divisions1-3. It has been proposed that the intercellular bridges connecting the cells, which are about 1 μm in diameter, permit the sharing of cytoplasmic constituents, thus ensuring the synchronous development of a clone of cells and gametic equivalence between haploid spermatids2,5,6. By analysing the product of a transgene which is expressed exclusively in post-meiotic germ cells in hemizygous transgenic mice, we have shown that genetically distinct spermatids share the product of the transgene and hence can be phenotypically equivalent.
AB - Because chromosomal homologues segregate from one another during meiosis, spermatids are genetically different. Post-meiotic gene expression could lead to gametic differences, some of which might lead to preferential transmission of certain alleles over others. In both insects and mammals, however, all the cells derived from a single spermatogonial cell develop within a common syncytium formed as a result of incomplete cytokinesis at each of the mitotic and meiotic cell divisions1-3. It has been proposed that the intercellular bridges connecting the cells, which are about 1 μm in diameter, permit the sharing of cytoplasmic constituents, thus ensuring the synchronous development of a clone of cells and gametic equivalence between haploid spermatids2,5,6. By analysing the product of a transgene which is expressed exclusively in post-meiotic germ cells in hemizygous transgenic mice, we have shown that genetically distinct spermatids share the product of the transgene and hence can be phenotypically equivalent.
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U2 - 10.1038/337373a0
DO - 10.1038/337373a0
M3 - Article
C2 - 2911388
AN - SCOPUS:0024586579
SN - 0028-0836
VL - 337
SP - 373
EP - 376
JO - Nature
JF - Nature
IS - 6205
ER -