Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor

Yuji Mishina; Atsushi Suzuki; Debra J. Gilbert; Neal G. Copeland; Nancy A. Jenkins; Naoto Ueno; Richard R. Behringer

doi:10.1006/bbrc.1995.1043

Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor

Yuji Mishina, Atsushi Suzuki, Debra J. Gilbert, Neal G. Copeland, Nancy A. Jenkins, Naoto Ueno, Richard R. Behringer

Genetics

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (>40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.

Original language	English (US)
Pages (from-to)	310-317
Number of pages	8
Journal	Biochemical and biophysical research communications
Volume	206
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.1995.1043
State	Published - Jan 5 1995

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1006/bbrc.1995.1043

Cite this

@article{e4c9011988a64dac8275f762add0cd77,

title = "Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor",

abstract = "We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (>40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.",

author = "Yuji Mishina and Atsushi Suzuki and Gilbert, {Debra J.} and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Naoto Ueno and Behringer, {Richard R.}",

year = "1995",

month = jan,

day = "5",

doi = "10.1006/bbrc.1995.1043",

language = "English (US)",

volume = "206",

pages = "310--317",

journal = "Biochemical and biophysical research communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor

AU - Mishina, Yuji

AU - Suzuki, Atsushi

AU - Gilbert, Debra J.

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Ueno, Naoto

AU - Behringer, Richard R.

PY - 1995/1/5

Y1 - 1995/1/5

N2 - We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (>40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.

AB - We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (>40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.

UR - http://www.scopus.com/inward/record.url?scp=0028796635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028796635&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1995.1043

DO - 10.1006/bbrc.1995.1043

M3 - Article

C2 - 7818535

AN - SCOPUS:0028796635

SN - 0006-291X

VL - 206

SP - 310

EP - 317

JO - Biochemical and biophysical research communications

JF - Biochemical and biophysical research communications

IS - 1

ER -

Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this