TY - JOUR
T1 - Genomic structure of newly identified paralogue of RNA helicase II/Gu
T2 - Detection of pseudogenes and multiple alternatively spliced mRNAs
AU - Valdez, Benigno C.
AU - Yang, Hushan
AU - Hong, Eugene
AU - Sequitin, Anne Marie
N1 - Funding Information:
This work was supported by a grant to B.C.V. from the National Institutes of Health (DK52341).
PY - 2002/2/6
Y1 - 2002/2/6
N2 - RNA helicase II/Gu (RH-II/Gu or DDX21) is a DEAD-box enzyme that localizes to the nucleoli and may be involved in ribosomal RNA synthesis or processing. It has two paralogues, RH-II/Guα and RH-II/Guβ, both genes of which are on chromosome 10. Their similar genomic structures suggest the two genes arose by gene duplication. Both genes are expressed at higher levels in some normal human tissues compared to matching tumor tissues. Pseudogenes for RH-II/Guβ exist on chromosomes 2, 3 and 4. No pseudogene was identified for RH-II/Guα. Both exon inclusion and exon skipping were found to post-transcriptionally regulate RH-II/Guβ gene expression. No alternative splicing was identified for RH-II/Guα. Overall, the results suggest that the two paralogues of RH-II/Gu arose by gene duplication but the resulting genes are differentially regulated.
AB - RNA helicase II/Gu (RH-II/Gu or DDX21) is a DEAD-box enzyme that localizes to the nucleoli and may be involved in ribosomal RNA synthesis or processing. It has two paralogues, RH-II/Guα and RH-II/Guβ, both genes of which are on chromosome 10. Their similar genomic structures suggest the two genes arose by gene duplication. Both genes are expressed at higher levels in some normal human tissues compared to matching tumor tissues. Pseudogenes for RH-II/Guβ exist on chromosomes 2, 3 and 4. No pseudogene was identified for RH-II/Guα. Both exon inclusion and exon skipping were found to post-transcriptionally regulate RH-II/Guβ gene expression. No alternative splicing was identified for RH-II/Guα. Overall, the results suggest that the two paralogues of RH-II/Gu arose by gene duplication but the resulting genes are differentially regulated.
KW - Alternative splicing
KW - Gene expression
KW - Gene structure
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U2 - 10.1016/S0378-1119(01)00888-5
DO - 10.1016/S0378-1119(01)00888-5
M3 - Article
C2 - 11891046
AN - SCOPUS:0037028492
SN - 0378-1119
VL - 284
SP - 53
EP - 61
JO - Gene
JF - Gene
IS - 1-2
ER -