Germline genetics in localized prostate cancer

Stephen T. Ryan; Vi Nguyen; Kelly K. Bree; Daniel D. Holst; A. Karim Kader

doi:10.1097/MOU.0000000000000648

Germline genetics in localized prostate cancer

Stephen T. Ryan, Vi Nguyen, Kelly K. Bree, Daniel D. Holst, A. Karim Kader

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Purpose of reviewTo provide the reader an understanding of the importance and limitations of prostate cancer (PCa) screening, the heritable component of PCa and the role that germline genetic markers can play in risk-adapted screening and treatment.Recent findingsDespite strong science supporting the association of germline genetic change with PCa risk and outcome, there has been a reluctance to pursue practical application of these technologies. Recent findings suggest that actionable information may now be garnered from this form of testing, which can help men at risk for and with PCa.SummaryThis is an exciting time whereby germline genetic markers can help overcome some of the shortcomings of current PCa screening and treatment paradigms. Understanding their benefit and limitations while keeping the patient's best interest in mind will be the key for the responsible application of these exciting technologies.

Original language	English (US)
Pages (from-to)	326-333
Number of pages	8
Journal	Current opinion in urology
Volume	29
Issue number	4
DOIs	https://doi.org/10.1097/MOU.0000000000000648
State	Published - Jul 1 2019
Externally published	Yes

Keywords

genetic screening
germline mutations
prostate cancer

ASJC Scopus subject areas

Urology

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10.1097/MOU.0000000000000648

Cite this

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abstract = "Purpose of reviewTo provide the reader an understanding of the importance and limitations of prostate cancer (PCa) screening, the heritable component of PCa and the role that germline genetic markers can play in risk-adapted screening and treatment.Recent findingsDespite strong science supporting the association of germline genetic change with PCa risk and outcome, there has been a reluctance to pursue practical application of these technologies. Recent findings suggest that actionable information may now be garnered from this form of testing, which can help men at risk for and with PCa.SummaryThis is an exciting time whereby germline genetic markers can help overcome some of the shortcomings of current PCa screening and treatment paradigms. Understanding their benefit and limitations while keeping the patient's best interest in mind will be the key for the responsible application of these exciting technologies.",

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AU - Ryan, Stephen T.

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AU - Bree, Kelly K.

AU - Holst, Daniel D.

AU - Kader, A. Karim

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AB - Purpose of reviewTo provide the reader an understanding of the importance and limitations of prostate cancer (PCa) screening, the heritable component of PCa and the role that germline genetic markers can play in risk-adapted screening and treatment.Recent findingsDespite strong science supporting the association of germline genetic change with PCa risk and outcome, there has been a reluctance to pursue practical application of these technologies. Recent findings suggest that actionable information may now be garnered from this form of testing, which can help men at risk for and with PCa.SummaryThis is an exciting time whereby germline genetic markers can help overcome some of the shortcomings of current PCa screening and treatment paradigms. Understanding their benefit and limitations while keeping the patient's best interest in mind will be the key for the responsible application of these exciting technologies.

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Germline genetics in localized prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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