TY - JOUR
T1 - Germline Predisposition to Myelodysplastic Syndromes
AU - Gener-Ricos, Georgina
AU - Gerstein, Yoheved S.
AU - Hammond, Danielle
AU - Dinardo, Courtney D.
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2023/5
Y1 - 2023/5
N2 - While germline predisposition to myelodysplastic syndromes is well-established, knowledge has advanced rapidly resulting in more cases of inherited hematologic malignancies being identified. Understanding the biological features and main clinical manifestations of hereditary hematologic malignancies is essential to recognizing and referring patients with myelodysplastic syndrome, who may underlie inherited predisposition, for appropriate genetic evaluation. Importance lies in individualized genetic counseling along with informed treatment decisions, especially with regard to hematopoietic stem cell transplant-related donor selection. Future studies will improve comprehension of these disorders, enabling better management of affected patients and their families.
AB - While germline predisposition to myelodysplastic syndromes is well-established, knowledge has advanced rapidly resulting in more cases of inherited hematologic malignancies being identified. Understanding the biological features and main clinical manifestations of hereditary hematologic malignancies is essential to recognizing and referring patients with myelodysplastic syndrome, who may underlie inherited predisposition, for appropriate genetic evaluation. Importance lies in individualized genetic counseling along with informed treatment decisions, especially with regard to hematopoietic stem cell transplant-related donor selection. Future studies will improve comprehension of these disorders, enabling better management of affected patients and their families.
KW - Bone marrow failure
KW - familial disorders
KW - germline predisposition
KW - hereditary
KW - myelodysplastic syndromes
UR - http://www.scopus.com/inward/record.url?scp=85159766797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85159766797&partnerID=8YFLogxK
U2 - 10.1097/PPO.0000000000000660
DO - 10.1097/PPO.0000000000000660
M3 - Article
C2 - 37195770
AN - SCOPUS:85159766797
SN - 1528-9117
VL - 29
SP - 143
EP - 151
JO - Cancer Journal (United States)
JF - Cancer Journal (United States)
IS - 3
ER -