Abstract
The fibroblast growth factor receptor-1 (FGFR-1) primary transcript is alternatively processed to produce receptors that vary in their ligand affinity and specificity. A high affinity form of this receptor-FGFR-1β- that lacks the α exon is observed on the neoplastic transformation of glial cells. In this study, we have identified a 62-bp sequence located 97 bp downstream from the α exon that is required for the exclusion of this exon in a human glioblastoma cell line. Deletion or mutation of this sequence is sufficient to allow enhanced inclusion of the α exon or a heterologous exon in glioblastoma cells. Therefore, it would appear that this sequence element plays a key role in the glioblastoma-specific splicing to form FGFR-1β mRNA.
Original language | English (US) |
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Pages (from-to) | 316-319 |
Number of pages | 4 |
Journal | Cancer Research |
Volume | 59 |
Issue number | 2 |
State | Published - Jan 16 1999 |
ASJC Scopus subject areas
- Oncology
- Cancer Research