Globe

For 2021, the American Cancer Society estimates that over 3300 patients in the United States were diagnosed with primary intraocular cancer [1]. The most common intraocular tumor in children is retinoblastoma (Rb) and in adults is uveal melanoma. Intraocular tumors may be classified based on their location. In children, this includes tumors of the retina such as Rb. Tumors may also arise in the iris and ciliary body, such as medulloepitheliomas, or involve the choroidal and retinal pigment epithelium (RPE), including hamartomas and congenital melanocytoma. Several benign vascular tumors of the globe include retinal angioma which is mainly related to the von Hippel–Lindau (VHL) syndrome and choroidal hemangioma. In adult patients, intraocular tumors include those of the iris, ciliary body, choroid, and RPE, such as nevi and metastatic melanoma. Remote tumors can also metastasize to the globe, with the vascular choroid being the most affected site.