Glutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy

Banu K. Arun; Laura A. Granville; Guosheng Yin; Lavinia P. Middleton; Shaheenah Dawood; Shu Wan Kau; Arif Kamal; Limin Hsu; Gabriel N. Hortobagyi; Aysegul A. Sahin

doi:10.3109/07357900903286925

Glutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy

Banu K. Arun, Laura A. Granville, Guosheng Yin, Lavinia P. Middleton, Shaheenah Dawood, Shu Wan Kau, Arif Kamal, Limin Hsu, Gabriel N. Hortobagyi, Aysegul A. Sahin

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23 Scopus citations

Abstract

Glutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 . There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p= .055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies.

Original language	English (US)
Pages (from-to)	554-559
Number of pages	6
Journal	Cancer Investigation
Volume	28
Issue number	5
DOIs	https://doi.org/10.3109/07357900903286925
State	Published - May 2010

Keywords

Breast cancer
Chemotherapy
Lutathione-S-transferase-pi
Prognosis and response predictions

ASJC Scopus subject areas

Oncology
Cancer Research

MD Anderson CCSG core facilities

Biostatistics Resource Group

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10.3109/07357900903286925

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title = "Glutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy",

abstract = "Glutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 . There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p= .055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies.",

keywords = "Breast cancer, Chemotherapy, Lutathione-S-transferase-pi, Prognosis and response predictions",

author = "Arun, {Banu K.} and Granville, {Laura A.} and Guosheng Yin and Middleton, {Lavinia P.} and Shaheenah Dawood and Kau, {Shu Wan} and Arif Kamal and Limin Hsu and Hortobagyi, {Gabriel N.} and Sahin, {Aysegul A.}",

year = "2010",

month = may,

doi = "10.3109/07357900903286925",

language = "English (US)",

volume = "28",

pages = "554--559",

journal = "Cancer Investigation",

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T1 - Glutathione-s-transferase-pi expression in early breast cancer

T2 - Association with outcome and response to chemotherapy

AU - Arun, Banu K.

AU - Granville, Laura A.

AU - Yin, Guosheng

AU - Middleton, Lavinia P.

AU - Dawood, Shaheenah

AU - Kau, Shu Wan

AU - Kamal, Arif

AU - Hsu, Limin

AU - Hortobagyi, Gabriel N.

AU - Sahin, Aysegul A.

PY - 2010/5

Y1 - 2010/5

N2 - Glutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 . There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p= .055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies.

AB - Glutathione-S-transferase-pi (GST-pi) is a detoxification enzyme expressed in breast cancer; however its involvement in chemotherapy sensitivity and prognosis is not well understood. We evaluated the expression of GSTpi and its predictive role of chemotherapy response. Breast tumor samples from 166 patients at stage I/II of the disease were immunostained for GST-pi, and the expression was 96 . There was a trend toward improved disease-free survival with high GST-pi expression (p =.09). There was a statistically non-significant association between high GST-pi expression and improved outcome with adjuvant chemotherapy (p= .055). Further studies should evaluate the role of GST-pi expression in relation to response to different chemotherapies.

KW - Breast cancer

KW - Chemotherapy

KW - Lutathione-S-transferase-pi

KW - Prognosis and response predictions

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JO - Cancer Investigation

JF - Cancer Investigation

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ER -

Glutathione-s-transferase-pi expression in early breast cancer: Association with outcome and response to chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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