TY - JOUR
T1 - Going circular
T2 - history, present, and future of circRNAs in cancer
AU - Pisignano, Giuseppina
AU - Michael, David C.
AU - Visal, Tanvi H.
AU - Pirlog, Radu
AU - Ladomery, Michael
AU - Calin, George A.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/9/15
Y1 - 2023/9/15
N2 - To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally and post-transcriptionally and exhibit distinct tissue- and development-specific expression patterns associated with a variety of normal and disease conditions, including cancer pathogenesis. Over the past years, due to their intrinsic stability and resistance to ribonucleases, particular attention has been drawn to their use as reliable diagnostic and prognostic biomarkers in cancer diagnosis, treatment, and prevention. However, there are some critical caveats to their utility in the clinic. Their circular shape limits their annotation and a complete functional elucidation is lacking. This makes their detection and biomedical application still challenging. Herein, we review the current knowledge of circRNA biogenesis and function, and of their involvement in tumorigenesis and potential utility in cancer-targeted therapy.
AB - To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally and post-transcriptionally and exhibit distinct tissue- and development-specific expression patterns associated with a variety of normal and disease conditions, including cancer pathogenesis. Over the past years, due to their intrinsic stability and resistance to ribonucleases, particular attention has been drawn to their use as reliable diagnostic and prognostic biomarkers in cancer diagnosis, treatment, and prevention. However, there are some critical caveats to their utility in the clinic. Their circular shape limits their annotation and a complete functional elucidation is lacking. This makes their detection and biomedical application still challenging. Herein, we review the current knowledge of circRNA biogenesis and function, and of their involvement in tumorigenesis and potential utility in cancer-targeted therapy.
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U2 - 10.1038/s41388-023-02780-w
DO - 10.1038/s41388-023-02780-w
M3 - Review article
C2 - 37587333
AN - SCOPUS:85168123307
SN - 0950-9232
VL - 42
SP - 2783
EP - 2800
JO - Oncogene
JF - Oncogene
IS - 38
ER -