TY - JOUR
T1 - Gold nanorod light scattering labels for biomedical imaging
AU - Qiu, Le
AU - Larson, Timothy A.
AU - Vitkin, Edward
AU - Guo, Lianyu
AU - Hanlon, Eugene B.
AU - Itzkan, Irving
AU - Sokolov, Konstantin V.
AU - Perelman, Lev T.
PY - 2010/8/2
Y1 - 2010/8/2
N2 - Gold nanorods can be used as extremely bright labels for differential light scattering measurements using two closely spaced wavelengths, thereby detecting human disease through several centimeters of tissue in vivo. They have excellent biocompatibility, are non-toxic, and are not susceptible to photobleaching. They have narrow, easily tunable plasmon spectral lines and thus can image multiple molecular targets simultaneously. Because of their small size, gold nanorods can be transported to various tissues inside the human body via the vasculature and microvasculature, and since they are smaller than vascular pore sizes, they can easily cross vascular space and enter individual cells.
AB - Gold nanorods can be used as extremely bright labels for differential light scattering measurements using two closely spaced wavelengths, thereby detecting human disease through several centimeters of tissue in vivo. They have excellent biocompatibility, are non-toxic, and are not susceptible to photobleaching. They have narrow, easily tunable plasmon spectral lines and thus can image multiple molecular targets simultaneously. Because of their small size, gold nanorods can be transported to various tissues inside the human body via the vasculature and microvasculature, and since they are smaller than vascular pore sizes, they can easily cross vascular space and enter individual cells.
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U2 - 10.1364/BOE.1.000135
DO - 10.1364/BOE.1.000135
M3 - Article
C2 - 21258453
AN - SCOPUS:79960849934
SN - 2156-7085
VL - 1
SP - 135
EP - 142
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 1
ER -