Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression

Chemin Lin; Chih Mao Huang; Helmet T. Karim; Ho Ling Liu; Tatia Mei Chun Lee; Changwei W. Wu; Cheng Hong Toh; Yun Fang Tsai; Tzung Hai Yen; Shwu Hua Lee

doi:10.1016/j.neurobiolaging.2020.12.016

Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression

Chemin Lin, Chih Mao Huang, Helmet T. Karim, Ho Ling Liu, Tatia Mei Chun Lee, Changwei W. Wu, Cheng Hong Toh, Yun Fang Tsai, Tzung Hai Yen, Shwu Hua Lee

Imaging Physics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Late-life depression (LLD) is associated with greater risk of suicide and white matter hyperintensities (WMH), which are also found in suicide attempters regardless of age. Greater periventricular WMH are related to worse cognitive function. We investigated the spatial distribution of WMH in suicide attempters with LLD and its association with cognitive function. We recruited 114 participants with LLD (34 with history of suicide attempt and 80 without) and 47 older adult controls (individuals without LLD or history of suicide attempt). WMH were quantified by an automated segmentation algorithm and were classified into different regions. Suicide attempters with LLD had significantly higher global WMH (F3, 150 = 2.856, p = 0.039) and periventricular WMH (F3, 150 = 3.635, p = 0.014) compared to other groups. Suicide attempters with high WMH had significantly lower executive function, which could be an underlying mechanism for cognitive decline in older adults with suicidality.

Original language	English (US)
Pages (from-to)	60-67
Number of pages	8
Journal	Neurobiology of Aging
Volume	103
DOIs	https://doi.org/10.1016/j.neurobiolaging.2020.12.016
State	Published - Jul 2021

Keywords

Cognitive function
Late-life depression
Periventricular white matter hyperintensity
Suicide
White matter hyperintensity

ASJC Scopus subject areas

General Neuroscience
Aging
Developmental Biology
Clinical Neurology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2020.12.016

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@article{68765d698d23421298e212c65a14025a,

title = "Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression",

abstract = "Late-life depression (LLD) is associated with greater risk of suicide and white matter hyperintensities (WMH), which are also found in suicide attempters regardless of age. Greater periventricular WMH are related to worse cognitive function. We investigated the spatial distribution of WMH in suicide attempters with LLD and its association with cognitive function. We recruited 114 participants with LLD (34 with history of suicide attempt and 80 without) and 47 older adult controls (individuals without LLD or history of suicide attempt). WMH were quantified by an automated segmentation algorithm and were classified into different regions. Suicide attempters with LLD had significantly higher global WMH (F3, 150 = 2.856, p = 0.039) and periventricular WMH (F3, 150 = 3.635, p = 0.014) compared to other groups. Suicide attempters with high WMH had significantly lower executive function, which could be an underlying mechanism for cognitive decline in older adults with suicidality.",

keywords = "Cognitive function, Late-life depression, Periventricular white matter hyperintensity, Suicide, White matter hyperintensity",

author = "Chemin Lin and Huang, {Chih Mao} and Karim, {Helmet T.} and Liu, {Ho Ling} and Lee, {Tatia Mei Chun} and Wu, {Changwei W.} and Toh, {Cheng Hong} and Tsai, {Yun Fang} and Yen, {Tzung Hai} and Lee, {Shwu Hua}",

note = "Funding Information: All data is available by request. All authors declare that no support, financial or otherwise, has been received from any organization that may have an interest in the submitted work; and (ii) there are no other relationships or activities that could appear to have influenced the submitted work. This study was approved by the Chang Gung Memorial Hospital Institutional Review Board and all participants gave written informed consent prior to participation. This study was supported by funding from Supported by (1) medical research grants CRRPG2K0021 from Chang Gung Memorial Hospital and NRRPG2H0031 from Ministry of Science and Technology, Taiwan to Chemin Lin (2) NMRPG3G6031/32 and NMRPG3J0121 from Ministry of Science and Technology, Taiwan to Shwu-Hua, Lee (3) the KKHo International Charitable Foundation to Tatia Lee. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = jul,

doi = "10.1016/j.neurobiolaging.2020.12.016",

language = "English (US)",

volume = "103",

pages = "60--67",

journal = "Neurobiology of Aging",

issn = "0197-4580",

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T1 - Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression

AU - Lin, Chemin

AU - Huang, Chih Mao

AU - Karim, Helmet T.

AU - Liu, Ho Ling

AU - Lee, Tatia Mei Chun

AU - Wu, Changwei W.

AU - Toh, Cheng Hong

AU - Tsai, Yun Fang

AU - Yen, Tzung Hai

AU - Lee, Shwu Hua

N1 - Funding Information: All data is available by request. All authors declare that no support, financial or otherwise, has been received from any organization that may have an interest in the submitted work; and (ii) there are no other relationships or activities that could appear to have influenced the submitted work. This study was approved by the Chang Gung Memorial Hospital Institutional Review Board and all participants gave written informed consent prior to participation. This study was supported by funding from Supported by (1) medical research grants CRRPG2K0021 from Chang Gung Memorial Hospital and NRRPG2H0031 from Ministry of Science and Technology, Taiwan to Chemin Lin (2) NMRPG3G6031/32 and NMRPG3J0121 from Ministry of Science and Technology, Taiwan to Shwu-Hua, Lee (3) the KKHo International Charitable Foundation to Tatia Lee. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2021/7

Y1 - 2021/7

N2 - Late-life depression (LLD) is associated with greater risk of suicide and white matter hyperintensities (WMH), which are also found in suicide attempters regardless of age. Greater periventricular WMH are related to worse cognitive function. We investigated the spatial distribution of WMH in suicide attempters with LLD and its association with cognitive function. We recruited 114 participants with LLD (34 with history of suicide attempt and 80 without) and 47 older adult controls (individuals without LLD or history of suicide attempt). WMH were quantified by an automated segmentation algorithm and were classified into different regions. Suicide attempters with LLD had significantly higher global WMH (F3, 150 = 2.856, p = 0.039) and periventricular WMH (F3, 150 = 3.635, p = 0.014) compared to other groups. Suicide attempters with high WMH had significantly lower executive function, which could be an underlying mechanism for cognitive decline in older adults with suicidality.

AB - Late-life depression (LLD) is associated with greater risk of suicide and white matter hyperintensities (WMH), which are also found in suicide attempters regardless of age. Greater periventricular WMH are related to worse cognitive function. We investigated the spatial distribution of WMH in suicide attempters with LLD and its association with cognitive function. We recruited 114 participants with LLD (34 with history of suicide attempt and 80 without) and 47 older adult controls (individuals without LLD or history of suicide attempt). WMH were quantified by an automated segmentation algorithm and were classified into different regions. Suicide attempters with LLD had significantly higher global WMH (F3, 150 = 2.856, p = 0.039) and periventricular WMH (F3, 150 = 3.635, p = 0.014) compared to other groups. Suicide attempters with high WMH had significantly lower executive function, which could be an underlying mechanism for cognitive decline in older adults with suicidality.

KW - Cognitive function

KW - Late-life depression

KW - Periventricular white matter hyperintensity

KW - Suicide

KW - White matter hyperintensity

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AN - SCOPUS:85103758720

SN - 0197-4580

VL - 103

SP - 60

EP - 67

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression

Abstract

Keywords

ASJC Scopus subject areas

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