Abstract
A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth.
Original language | English (US) |
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Pages (from-to) | 2827-2833 |
Number of pages | 7 |
Journal | Endocrinology |
Volume | 123 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology