Guanine binding to dirhodium tetracarboxylate anticancer complexes: Quantum chemical calculations unravel an elusive mechanism

Dirk V. Deubel; Helen T. Chifotides

doi:10.1039/b709209a

Guanine binding to dirhodium tetracarboxylate anticancer complexes: Quantum chemical calculations unravel an elusive mechanism

Dirk V. Deubel, Helen T. Chifotides

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The reaction mechanism leading to metalated DNA fragments in which guanine-N7,O6 spans the metal-metal bond of dirhodium antitumour complexes in a bridging fashion at equatorial sites has been unravelled by a comprehensive prediction of intermediates and transition states.

Original language	English (US)
Pages (from-to)	3438-3440
Number of pages	3
Journal	Chemical Communications
Issue number	33
DOIs	https://doi.org/10.1039/b709209a
State	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b709209a

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title = "Guanine binding to dirhodium tetracarboxylate anticancer complexes: Quantum chemical calculations unravel an elusive mechanism",

abstract = "The reaction mechanism leading to metalated DNA fragments in which guanine-N7,O6 spans the metal-metal bond of dirhodium antitumour complexes in a bridging fashion at equatorial sites has been unravelled by a comprehensive prediction of intermediates and transition states.",

author = "Deubel, {Dirk V.} and Chifotides, {Helen T.}",

year = "2007",

doi = "10.1039/b709209a",

language = "English (US)",

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journal = "Chemical Communications",

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T2 - Quantum chemical calculations unravel an elusive mechanism

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N2 - The reaction mechanism leading to metalated DNA fragments in which guanine-N7,O6 spans the metal-metal bond of dirhodium antitumour complexes in a bridging fashion at equatorial sites has been unravelled by a comprehensive prediction of intermediates and transition states.

AB - The reaction mechanism leading to metalated DNA fragments in which guanine-N7,O6 spans the metal-metal bond of dirhodium antitumour complexes in a bridging fashion at equatorial sites has been unravelled by a comprehensive prediction of intermediates and transition states.

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U2 - 10.1039/b709209a

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JO - Chemical Communications

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Guanine binding to dirhodium tetracarboxylate anticancer complexes: Quantum chemical calculations unravel an elusive mechanism

Abstract

ASJC Scopus subject areas

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