TY - JOUR
T1 - Guidelines for the Prevention and Management of Graft-versus-Host Disease after Cord Blood Transplantation
AU - American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group
AU - Ponce, Doris M.
AU - Politikos, Ioannis
AU - Alousi, Amin
AU - Carpenter, Paul A.
AU - Milano, Filippo
AU - MacMillan, Margaret L.
AU - Barker, Juliet N.
AU - Horwitz, Mitchell E.
N1 - Publisher Copyright:
© 2021 The American Society for Transplantation and Cellular Therapy
PY - 2021/7
Y1 - 2021/7
N2 - The incidence of graft-versus-host disease (GVHD) after cord blood (CB) transplantation (CBT) is lower than expected given the marked degree of human leukocyte antigen (HLA)-mismatch of CB grafts. While the exact mechanism that underlies this biology remains unclear, it is hypothesized to be due to the low number of mostly immature T-cells infused as part of the graft1,2, and increased tolerance of CB-derived lymphocytes induced by the state of pregnancy. Nevertheless, acute GVHD (aGVHD) is a significant complication of CBT. In contrast, the incidence of chronic GVHD (cGVHD) following CBT is lower than what is observed following matched related or unrelated donor HSC transplantation (HSCT)3-6. This review outlines the guidelines for the prevention and management of acute and chronic GVHD following CBT.
AB - The incidence of graft-versus-host disease (GVHD) after cord blood (CB) transplantation (CBT) is lower than expected given the marked degree of human leukocyte antigen (HLA)-mismatch of CB grafts. While the exact mechanism that underlies this biology remains unclear, it is hypothesized to be due to the low number of mostly immature T-cells infused as part of the graft1,2, and increased tolerance of CB-derived lymphocytes induced by the state of pregnancy. Nevertheless, acute GVHD (aGVHD) is a significant complication of CBT. In contrast, the incidence of chronic GVHD (cGVHD) following CBT is lower than what is observed following matched related or unrelated donor HSC transplantation (HSCT)3-6. This review outlines the guidelines for the prevention and management of acute and chronic GVHD following CBT.
KW - Cord blood transplant
KW - Graft-versus-host disease
UR - http://www.scopus.com/inward/record.url?scp=85110274961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85110274961&partnerID=8YFLogxK
U2 - 10.1016/j.jtct.2021.03.012
DO - 10.1016/j.jtct.2021.03.012
M3 - Article
C2 - 34210500
AN - SCOPUS:85110274961
SN - 2666-6367
VL - 27
SP - 540
EP - 544
JO - Transplantation and Cellular Therapy
JF - Transplantation and Cellular Therapy
IS - 7
ER -