@article{a93e363032664bbeb72a1cd4bb4a8200,
title = "Gut Microbes{\textquoteright} Impact on Oncogenic Drivers: Location Matters",
abstract = "Recent work by Kadosh et al. (2020) suggests that mutant p53 activity in gut epithelia is influenced by local production of microbial metabolites. The switch of p53 from tumor suppressor to oncogene is location-dependent and is impacted by microbially derived gallic acid.",
author = "White, {Michael G.} and Wargo, {Jennifer A.}",
note = "Funding Information: J.A.W. is supported by the NIH (1 R01 CA219896-01A1), U.S-Israel Binational Science Foundation (201332), the Melanoma Research Alliance (4022024), American Association for Cancer Research Stand Up To Cancer (SU2C-AACR-IRG-19-17), Department of Defense (W81XWH-16-1-0121), MD Anderson Cancer Center Multidisciplinary Research Program Grant, Andrew Sabin Family Fellows Program, and MD Anderson Cancer Center's Melanoma Moon Shots Program. J.A.W. is a member of the Parker Institute for Cancer Immunotherapy at MD Anderson Cancer Center. J.A.W. is an inventor on a US patent application (PCT/US17/53.717) submitted by the University of Texas MD Anderson Cancer Center that covers methods to enhance immune checkpoint blockade responses by modulating the microbiome. J.A.W. reports compensation for speaker's bureau and honoraria from Imedex, Dava Oncology, Omniprex, Illumina, Gilead, PeerView, Physician Education Resource, MedImmune, and Bristol-Myers Squibb. J.A.W. serves as a consultant/advisory board member for Roche/Genentech, Novartis, AstraZeneca, GlaxoSmithKline, Bristol-Myers Squibb, Merck, Biothera Pharmaceuticals, and Microbiome DX. J.A.W. also receives research support from GlaxoSmithKline, Roche/Genentech, Bristol-Myers Squibb, and Novartis. Funding Information: J.A.W. is supported by the NIH ( 1 R01 CA219896-01A1 ), U.S-Israel Binational Science Foundation ( 201332 ), the Melanoma Research Alliance ( 4022024 ), American Association for Cancer Research Stand Up To Cancer ( SU2C-AACR-IRG-19-17 ), Department of Defense ( W81XWH-16-1-0121 ), MD Anderson Cancer Center Multidisciplinary Research Program Grant , Andrew Sabin Family Fellows Program , and MD Anderson Cancer Center{\textquoteright}s Melanoma Moon Shots Program . J.A.W. is a member of the Parker Institute for Cancer Immunotherapy at MD Anderson Cancer Center. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = sep,
day = "17",
doi = "10.1016/j.molcel.2020.08.021",
language = "English (US)",
volume = "79",
pages = "878--880",
journal = "Molecular cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",
}