Hürthle Cell Tumors of the Thyroid: A Flow Cytometric DNA Analysis

Adel K. El-Naggar; John G. Batsakis; Mario A. Luna; Robert C. Hickey

doi:10.1001/archotol.1988.01860170050016

Hürthle Cell Tumors of the Thyroid: A Flow Cytometric DNA Analysis

Adel K. El-Naggar, John G. Batsakis, Mario A. Luna, Robert C. Hickey

Pathology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

• Twenty-five Hürthle cell tumors of the thyroid gland, histopathologically classified into three groups—adenomas, carcinomas, and indeterminant—have been studied by DNA flow cytometry using archived, paraffin-embedded tissues. Tumor ploidy characteristics were correlated with patient follow-up and survival with the conclusions that (1) nuclear DNA ploidy alone does not distinguish benign from malignant Hürthle cell tumors; (2) diploid DNA Hürthle cell carcinomas behave far less aggressively than aneuploid Hürthle cell carcinomas; and (3) all patients with aneuploid carcinomas died of their disease or are alive with persistent carcinoma. (Arch Otolaryngol Head Neck Surg 1988;114:520-521).

Original language	English (US)
Pages (from-to)	520-521
Number of pages	2
Journal	Archives of Otolaryngology--Head and Neck Surgery
Volume	114
Issue number	5
DOIs	https://doi.org/10.1001/archotol.1988.01860170050016
State	Published - May 1988

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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10.1001/archotol.1988.01860170050016

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title = "H{\"u}rthle Cell Tumors of the Thyroid: A Flow Cytometric DNA Analysis",

abstract = "• Twenty-five H{\"u}rthle cell tumors of the thyroid gland, histopathologically classified into three groups—adenomas, carcinomas, and indeterminant—have been studied by DNA flow cytometry using archived, paraffin-embedded tissues. Tumor ploidy characteristics were correlated with patient follow-up and survival with the conclusions that (1) nuclear DNA ploidy alone does not distinguish benign from malignant H{\"u}rthle cell tumors; (2) diploid DNA H{\"u}rthle cell carcinomas behave far less aggressively than aneuploid H{\"u}rthle cell carcinomas; and (3) all patients with aneuploid carcinomas died of their disease or are alive with persistent carcinoma. (Arch Otolaryngol Head Neck Surg 1988;114:520-521).",

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AU - El-Naggar, Adel K.

AU - Batsakis, John G.

AU - Luna, Mario A.

AU - Hickey, Robert C.

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AB - • Twenty-five Hürthle cell tumors of the thyroid gland, histopathologically classified into three groups—adenomas, carcinomas, and indeterminant—have been studied by DNA flow cytometry using archived, paraffin-embedded tissues. Tumor ploidy characteristics were correlated with patient follow-up and survival with the conclusions that (1) nuclear DNA ploidy alone does not distinguish benign from malignant Hürthle cell tumors; (2) diploid DNA Hürthle cell carcinomas behave far less aggressively than aneuploid Hürthle cell carcinomas; and (3) all patients with aneuploid carcinomas died of their disease or are alive with persistent carcinoma. (Arch Otolaryngol Head Neck Surg 1988;114:520-521).

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Hürthle Cell Tumors of the Thyroid: A Flow Cytometric DNA Analysis

Abstract

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