Abstract
Male hybrids from a cross between female mice of strain C57BL/6Kh and males of strain DBA/2J lived longer after injection of P815 mastocytoma cells of DBA/2 origin than did their female siblings. Responses to the histocompatibility antigen on the X chromosome of the DBA/2 strain may be involved in resistance to the tumor. When the female parent was replaced with a C57BL/6Kh carrying one of several mutations in the H-2 region, this sex effect disappeared in some of the hybrid combinations. Thus, the H-2 complex appears to be involved in the regulation of the immune response to the X-linked histocompatibility antigen in this tumor model.
Original language | English (US) |
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Pages (from-to) | 959-961 |
Number of pages | 3 |
Journal | Science |
Volume | 220 |
Issue number | 4600 |
DOIs | |
State | Published - May 27 1983 |
ASJC Scopus subject areas
- General