Abstract
Here, we found that a 6-mer peptide, Poly6, derived from the hepatitis B virus (HBV), which overlaps with a polymerase corresponding to a preS1 deletion reported to contribute to liver disease progression, can elicit an antiviral effect against human immunodeficiency virus (HIV)-1 by inhibiting HIV-1 integrase (IN) activity of infected cells. Mechanistic studies revealed that the anti-HIV-1 effects of Poly6 occurred via the inhibition of integration, which resulted from the inhibition of acetylation of HIV-1 IN possibly by downregulation of p300 histone acetyltransferase. Our data suggest the potential therapeutic use of a 6-mer HBV-derived peptide, Poly6, as an anti-HIV-1 agent to suppress HIV-1 infection via inhibiting integrase activity.
Original language | English (US) |
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Pages (from-to) | 541-546 |
Number of pages | 6 |
Journal | Biochemical and biophysical research communications |
Volume | 501 |
Issue number | 2 |
DOIs | |
State | Published - Jun 22 2018 |
Externally published | Yes |
Keywords
- Hepatitis B virus
- Human immunodeficiency virus
- Integrase
- Peptide
- Poly6
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology