Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome

Andrés Coca-Pelaz; Robert P. Takes; Kate Hutcheson; Nabil F. Saba; Missak Haigentz; Carol R. Bradford; Remco de Bree; Primož Strojan; Valerie J. Lund; William M. Mendenhall; Iain J. Nixon; Miquel Quer; Alessandra Rinaldo; Alfio Ferlito

doi:10.1007/s12325-018-0663-7

Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome

Andrés Coca-Pelaz, Robert P. Takes, Kate Hutcheson, Nabil F. Saba, Missak Haigentz, Carol R. Bradford, Remco de Bree, Primož Strojan, Valerie J. Lund, William M. Mendenhall, Iain J. Nixon, Miquel Quer, Alessandra Rinaldo, Alfio Ferlito

Head & Neck Surgery

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

Original language	English (US)
Pages (from-to)	153-160
Number of pages	8
Journal	Advances in Therapy
Volume	35
Issue number	2
DOIs	https://doi.org/10.1007/s12325-018-0663-7
State	Published - Feb 1 2018

Keywords

Head and neck cancer
Oncology
Prognosis
Survival
Treatment
Waiting time

ASJC Scopus subject areas

Pharmacology (medical)

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10.1007/s12325-018-0663-7

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title = "Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome",

abstract = "Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).",

keywords = "Head and neck cancer, Oncology, Prognosis, Survival, Treatment, Waiting time",

author = "Andr{\'e}s Coca-Pelaz and Takes, {Robert P.} and Kate Hutcheson and Saba, {Nabil F.} and Missak Haigentz and Bradford, {Carol R.} and {de Bree}, Remco and Primo{\v z} Strojan and Lund, {Valerie J.} and Mendenhall, {William M.} and Nixon, {Iain J.} and Miquel Quer and Alessandra Rinaldo and Alfio Ferlito",

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doi = "10.1007/s12325-018-0663-7",

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AU - Coca-Pelaz, Andrés

AU - Takes, Robert P.

AU - Hutcheson, Kate

AU - Saba, Nabil F.

AU - Haigentz, Missak

AU - Bradford, Carol R.

AU - de Bree, Remco

AU - Strojan, Primož

AU - Lund, Valerie J.

AU - Mendenhall, William M.

AU - Nixon, Iain J.

AU - Quer, Miquel

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

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AB - Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

KW - Head and neck cancer

KW - Oncology

KW - Prognosis

KW - Survival

KW - Treatment

KW - Waiting time

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Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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