TY - JOUR
T1 - Head and neck inflammatory pseudotumor
T2 - Case series and review of the literature
AU - Kansara, Sagar
AU - Bell, Diana
AU - Johnson, Jason
AU - Zafereo, Mark
N1 - Publisher Copyright:
© The Author(s) 2016.
PY - 2016/12
Y1 - 2016/12
N2 - Inflammatory pseudotumor (IP) is an uncommon idiopathic lesion that often imitates malignancy clinically and radiologically. Inflammatory pseudotumors have been found to occur in various sites but rarely in the head and neck. The histopathology, imaging, and treatment of three unique cases of head and neck inflammatory pseudotumors are described in this case series. Patients in Cases 1 and 2 presented with right level II neck mass and left parotid tail mass, respectively. The patient in Case 3 presented with otalgia, jaw pain and trismus, and a left parapharyngeal space mass. The tumors in Cases 1 and 3 significantly decreased in size with tapered courses of oral corticosteroids. The tumor in Case 2 was surgically excised without disease recurrence. Malignancy must be ruled out with incisional or excisional biopsy. Treatment includes surgical excision, oral corticosteroids, or both. The literature shows that radiotherapy and small-molecule inhibitors may be promising alternatives.
AB - Inflammatory pseudotumor (IP) is an uncommon idiopathic lesion that often imitates malignancy clinically and radiologically. Inflammatory pseudotumors have been found to occur in various sites but rarely in the head and neck. The histopathology, imaging, and treatment of three unique cases of head and neck inflammatory pseudotumors are described in this case series. Patients in Cases 1 and 2 presented with right level II neck mass and left parotid tail mass, respectively. The patient in Case 3 presented with otalgia, jaw pain and trismus, and a left parapharyngeal space mass. The tumors in Cases 1 and 3 significantly decreased in size with tapered courses of oral corticosteroids. The tumor in Case 2 was surgically excised without disease recurrence. Malignancy must be ruled out with incisional or excisional biopsy. Treatment includes surgical excision, oral corticosteroids, or both. The literature shows that radiotherapy and small-molecule inhibitors may be promising alternatives.
KW - Head and neck neoplasms
KW - Head and neck oncology
KW - IgG4 disease
KW - Inflammatory pseudotumor
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U2 - 10.1177/1971400916665377
DO - 10.1177/1971400916665377
M3 - Article
C2 - 27650653
AN - SCOPUS:85014093674
SN - 1971-4009
VL - 29
SP - 440
EP - 446
JO - Neuroradiology Journal
JF - Neuroradiology Journal
IS - 6
ER -