TY - JOUR
T1 - Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact
T2 - A longitudinal study
AU - Wen, Zhengwei
AU - Li, Xiaomei
AU - Lu, Qian
AU - Brunson, Julie
AU - Zhao, Miao
AU - Tan, Jianfeng
AU - Wan, Chonghua
AU - Lei, Pingguang
N1 - Funding Information:
Supported by the National Natural Science Foundation of China (30860248), the Key Discipline and Science & Technology Innovation Fund of Guangdong Medical College (XZ1111, STIF201119).
Publisher Copyright:
© 2014 Wen et al.; licensee BioMed Central Ltd.
PY - 2014/8/20
Y1 - 2014/8/20
N2 - Background: The assessment of Health Related Quality of Life (HRQOL) has been applied as a significant outcome indicator for patients with chronic diseases. No HRQOL study, however, has looked at HRQOL in patients with chronic gastritis and peptic ulcers. This paper focuses on comparing HRQOL in patients with chronic gastritis and peptic ulcers and examining the factors that influence the HRQOL of such patients. Results can be used for making decisions in clinical trials as well as aiding individual management and preventive care of these diseases.Methods: The Chinese version of the SF-36 (CSF-36) was administered twice to 244 patients with chronic gastritis and peptic ulcers. Mean scores across the two disease groups were compared using t-tests, change over time was analyzed with paired samples t-tests, and factors predicting HRQOL were investigated using the univariate general linear model.Results: The mean domain scores of patients with chronic gastritis were lower than those for patients with peptic ulcers, with the exception of physical functioning. Both groups had lower HRQOL compared with population norms. Mean domain scores increased after treatment in both groups. HRQOL in patients with these two chronic diseases differed by age, education level, marriage, income, and gender, but their explanatory power was relatively low.Conclusion: Quality of life of patients with chronic gastritis was lower than that of patients with peptic ulcers, which was lower than population norms. Quality of life in both patients groups was associated with socio-demographic risk factors.
AB - Background: The assessment of Health Related Quality of Life (HRQOL) has been applied as a significant outcome indicator for patients with chronic diseases. No HRQOL study, however, has looked at HRQOL in patients with chronic gastritis and peptic ulcers. This paper focuses on comparing HRQOL in patients with chronic gastritis and peptic ulcers and examining the factors that influence the HRQOL of such patients. Results can be used for making decisions in clinical trials as well as aiding individual management and preventive care of these diseases.Methods: The Chinese version of the SF-36 (CSF-36) was administered twice to 244 patients with chronic gastritis and peptic ulcers. Mean scores across the two disease groups were compared using t-tests, change over time was analyzed with paired samples t-tests, and factors predicting HRQOL were investigated using the univariate general linear model.Results: The mean domain scores of patients with chronic gastritis were lower than those for patients with peptic ulcers, with the exception of physical functioning. Both groups had lower HRQOL compared with population norms. Mean domain scores increased after treatment in both groups. HRQOL in patients with these two chronic diseases differed by age, education level, marriage, income, and gender, but their explanatory power was relatively low.Conclusion: Quality of life of patients with chronic gastritis was lower than that of patients with peptic ulcers, which was lower than population norms. Quality of life in both patients groups was associated with socio-demographic risk factors.
KW - Chronic digestive disease
KW - Health-related quality of life
KW - Influence factors
KW - SF-36
KW - Standardized response mean
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U2 - 10.1186/1471-230X-14-149
DO - 10.1186/1471-230X-14-149
M3 - Article
C2 - 25141760
AN - SCOPUS:84908393914
SN - 1471-230X
VL - 14
JO - BMC Gastroenterology
JF - BMC Gastroenterology
IS - 1
M1 - 149
ER -