Abstract
In vitro and in vivo studies were conducted to obtain basic information on the activity of gamma interferon (IFN-γ) in acute myelogenous leukemia (AML). In a selected case of AML, recombinant IFN-γ, but not IFN-α, induced differentiation of primary leukemic blasts in vitro. Similarly, IFN-γ inhibited leukemic colony formation in vitro. This contrasted with IFN-α which was inactive. In one case of AML (M2), partially purified IFN-γ given intravenously caused a shift of the WBC profile from immature blasts to maturing myeloid cells and neutrophil granulocytes. Intravenous IFN-γ treatment of another patient who had AML as a second malignancy resulted in a complete hematologic remission, normalization of marrow granulocyte-macrophage colony-forming cell in vitro growth, and conversion of marrow cytogenetics from 95% hyperdiploid clone with complex abnormalities into 100% diploid. The results indicate a potential use of IFN-γ in the treatment of selected patients with AML and the possibility of in vitro pretreatment evaluation of these patients' leukemic response to IFNs.
Original language | English (US) |
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Pages (from-to) | 52-57 |
Number of pages | 6 |
Journal | Leukemia |
Volume | 1 |
Issue number | 1 |
State | Published - 1987 |
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research