Abstract
Brentuximab vedotin (BV), an antibody-drug conjugate that targets CD30, induces high response rates in CD30+ lymphoid malignancies. It is unknown if BV use affects procurement of autologous CD34+ stem cells and hematopoietic engraftment after autologous stem cell transplantation (ASCT). We examined 42 patients treated with BV before mobilization. Median times from diagnosis to transplantation, from initial BV treatment to transplantation, and from last BV treatment to stem cell collection were 21 months (range, 10 to 210), 5 months (range, 1.5 to 16.8), and 30 days (range, 2 to 280), respectively. Mobilization was successful on the first attempt in 38 patients (90.4%). The median number of infused CD34+ cells was 5.46× 106/kg (range, 1.65 to 54.78× 106/kg). The median times to neutrophil and platelet engraftment were 10 (range, 9 to 13), and 10.5 days (range, 7 to 35), respectively. BV before high-dose chemotherapy-ASCT did not adversely affect peripheral blood stem cell mobilization and subsequent engraftment in a cohort of heavily pretreated patients with CD30+ lymphomas.
Original language | English (US) |
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Pages (from-to) | 1529-1531 |
Number of pages | 3 |
Journal | Biology of Blood and Marrow Transplantation |
Volume | 21 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2015 |
Keywords
- Autologous transplantation
- Brentuximab
- Mobilization
ASJC Scopus subject areas
- Hematology
- Transplantation
MD Anderson CCSG core facilities
- Clinical Trials Office