TY - JOUR
T1 - Hematopoietic stem cell transplantation for chronic lymphocytic leukemia
AU - Khouri, Issa F.
AU - Keating, Michael J.
AU - Champlin, Richard
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1998
Y1 - 1998
N2 - Conventional therapies for chronic lymphocytic leukemia are not likely to provide a cure, prompting the use of more aggressive approaches. High-dose therapy with autologous and allogeneic bone marrow or blood stem cell transplantation appear to induce a prolonged period of disease-free survival in selected patients with this indolent disease. Significant questions were raised, however, in terms of survival benefit, the value of purging, the presence of graft-versus-leukemia effect, and the timing of transplantation. The survey presents the main results obtained in the area of transplantation for chronic lymphocytic leukemia and critically discusses them in light of the current debate.
AB - Conventional therapies for chronic lymphocytic leukemia are not likely to provide a cure, prompting the use of more aggressive approaches. High-dose therapy with autologous and allogeneic bone marrow or blood stem cell transplantation appear to induce a prolonged period of disease-free survival in selected patients with this indolent disease. Significant questions were raised, however, in terms of survival benefit, the value of purging, the presence of graft-versus-leukemia effect, and the timing of transplantation. The survey presents the main results obtained in the area of transplantation for chronic lymphocytic leukemia and critically discusses them in light of the current debate.
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U2 - 10.1097/00062752-199811000-00017
DO - 10.1097/00062752-199811000-00017
M3 - Review article
C2 - 9814655
AN - SCOPUS:0031773618
SN - 1065-6251
VL - 5
SP - 454
EP - 459
JO - Current opinion in hematology
JF - Current opinion in hematology
IS - 6
ER -