Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Shubham Pant; Edward A. Copelan

doi:10.1016/j.bbmt.2007.05.002

Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Shubham Pant, Edward A. Copelan

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

High-dose therapy and autologous hematopoietic stem cell transplantation are standard early treatment of patients with multiple myeloma. Tandem transplantation appears to provide additional benefit, particularly in patients with limited response to initial transplantation. Myeloablative allogeneic transplantation provides the only potential for cure, but has been largely abandoned because of high mortality rates. Newer and better induction regimens, rigorous analysis of results with autologous and allogeneic transplantation, and the development of risk-adapted stratification provide the impetus for this critical evaluation of the role of hematopoietic stem cell transplantation in multiple myeloma.

Original language	English (US)
Pages (from-to)	877-885
Number of pages	9
Journal	Biology of Blood and Marrow Transplantation
Volume	13
Issue number	8
DOIs	https://doi.org/10.1016/j.bbmt.2007.05.002
State	Published - Aug 2007
Externally published	Yes

Keywords

Hematopoietic stem cell transplantation
Multiple myeloma

ASJC Scopus subject areas

Hematology
Transplantation

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10.1016/j.bbmt.2007.05.002

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title = "Hematopoietic Stem Cell Transplantation in Multiple Myeloma",

abstract = "High-dose therapy and autologous hematopoietic stem cell transplantation are standard early treatment of patients with multiple myeloma. Tandem transplantation appears to provide additional benefit, particularly in patients with limited response to initial transplantation. Myeloablative allogeneic transplantation provides the only potential for cure, but has been largely abandoned because of high mortality rates. Newer and better induction regimens, rigorous analysis of results with autologous and allogeneic transplantation, and the development of risk-adapted stratification provide the impetus for this critical evaluation of the role of hematopoietic stem cell transplantation in multiple myeloma.",

keywords = "Hematopoietic stem cell transplantation, Multiple myeloma",

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journal = "Biology of Blood and Marrow Transplantation",

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T1 - Hematopoietic Stem Cell Transplantation in Multiple Myeloma

AU - Pant, Shubham

AU - Copelan, Edward A.

PY - 2007/8

Y1 - 2007/8

N2 - High-dose therapy and autologous hematopoietic stem cell transplantation are standard early treatment of patients with multiple myeloma. Tandem transplantation appears to provide additional benefit, particularly in patients with limited response to initial transplantation. Myeloablative allogeneic transplantation provides the only potential for cure, but has been largely abandoned because of high mortality rates. Newer and better induction regimens, rigorous analysis of results with autologous and allogeneic transplantation, and the development of risk-adapted stratification provide the impetus for this critical evaluation of the role of hematopoietic stem cell transplantation in multiple myeloma.

AB - High-dose therapy and autologous hematopoietic stem cell transplantation are standard early treatment of patients with multiple myeloma. Tandem transplantation appears to provide additional benefit, particularly in patients with limited response to initial transplantation. Myeloablative allogeneic transplantation provides the only potential for cure, but has been largely abandoned because of high mortality rates. Newer and better induction regimens, rigorous analysis of results with autologous and allogeneic transplantation, and the development of risk-adapted stratification provide the impetus for this critical evaluation of the role of hematopoietic stem cell transplantation in multiple myeloma.

KW - Hematopoietic stem cell transplantation

KW - Multiple myeloma

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U2 - 10.1016/j.bbmt.2007.05.002

DO - 10.1016/j.bbmt.2007.05.002

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SN - 1083-8791

VL - 13

SP - 877

EP - 885

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 8

ER -

Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Abstract

Keywords

ASJC Scopus subject areas

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