TY - JOUR
T1 - Hemodynamic effects of experimental acute right ventricular overload
AU - Filho, Flávio Brito
AU - de Campos, Kleber Nogueira
AU - de Oliveira, Humberto Alves
AU - Fernandes, Josué
AU - Melo e Silva, César Augusto
AU - Gaio, Eduardo
AU - Parra, Edwin Roger
AU - de Carvalho, Paulo Henrique Cândido
AU - Fernandes, Paulo Manuel Pêgo
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2011
Y1 - 2011
N2 - Background: Acute right ventricular overload is associated with high morbidity and mortality clinical situations such as: extensive lung resection, pulmonary thromboembolism, lung transplantation and high altitude pulmonary edema. Some points of its pathophysiology remain unclear. Objective: To assess the hemodynamic effects of experimental acute right ventricular overload in pigs. Methods: Right ventricular overload was induced through the occlusion of the pulmonary arteries using ligationss. Twenty pigs were used in the study, divided into 04 groups: one control group not subject to pulmonary vascular occlusion, and three right ventricular overload groups subject to occlusion of the following pulmonary arteries: SVD1 (left pulmonary artery); SVD2 (left pulmonary artery and right lower lobe) and SVD3 (left pulmonary artery, right lower lobe and mediastinal lobe), obstructing the pulmonary vasculature in 42, 76 and 82.0% respectively. Hemodynamic variables were measured every 15 minutes during one hour of study. The statistical analysis employed mixed linear models with variance and covariance structures. Results: Group comparisons revealed significant increases in heart rate (p = 0.004), mean pulmonary artery pressure (p = 0.001) and pulmonary capillary wedge pressure (p < 0.0001). There was no significant difference in cardiac index (p = 0.94). Conclusion: Despite the severe right ventricular overload promoted by 82.0% obstruction of the pulmonary vasculature and the significant increase in pulmonary arterial pressure, there was no severe cardiovascular dysfunction and/or circulatory shock during the study period.
AB - Background: Acute right ventricular overload is associated with high morbidity and mortality clinical situations such as: extensive lung resection, pulmonary thromboembolism, lung transplantation and high altitude pulmonary edema. Some points of its pathophysiology remain unclear. Objective: To assess the hemodynamic effects of experimental acute right ventricular overload in pigs. Methods: Right ventricular overload was induced through the occlusion of the pulmonary arteries using ligationss. Twenty pigs were used in the study, divided into 04 groups: one control group not subject to pulmonary vascular occlusion, and three right ventricular overload groups subject to occlusion of the following pulmonary arteries: SVD1 (left pulmonary artery); SVD2 (left pulmonary artery and right lower lobe) and SVD3 (left pulmonary artery, right lower lobe and mediastinal lobe), obstructing the pulmonary vasculature in 42, 76 and 82.0% respectively. Hemodynamic variables were measured every 15 minutes during one hour of study. The statistical analysis employed mixed linear models with variance and covariance structures. Results: Group comparisons revealed significant increases in heart rate (p = 0.004), mean pulmonary artery pressure (p = 0.001) and pulmonary capillary wedge pressure (p < 0.0001). There was no significant difference in cardiac index (p = 0.94). Conclusion: Despite the severe right ventricular overload promoted by 82.0% obstruction of the pulmonary vasculature and the significant increase in pulmonary arterial pressure, there was no severe cardiovascular dysfunction and/or circulatory shock during the study period.
KW - Catheterization
KW - Pulmonary embolism
KW - Right
KW - Swan-Ganz
KW - Swine
KW - Ventricular dysfunction
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U2 - 10.1590/S0066-782X2011005000029
DO - 10.1590/S0066-782X2011005000029
M3 - Article
C2 - 21359476
AN - SCOPUS:79957908214
SN - 0066-782X
VL - 96
SP - 284
EP - 291
JO - Arquivos brasileiros de cardiologia
JF - Arquivos brasileiros de cardiologia
IS - 4
ER -