Hepatic apolipoprotein B biogenesis: An update

Jim Yeung Sai-Ching; Lawrence Chan

doi:10.1016/S1050-1738(97)00120-5

Hepatic apolipoprotein B biogenesis: An update

Jim Yeung Sai-Ching, Lawrence Chan

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Approximately one half to two thirds of newly synthesized apolipoprotein B (apoB) in Hep G2 cells (a human hepatoma cell line) is degraded. The intracellular degradation of apoB associated with the rough endoplasmic reticulum (ER) is reviewed in the context of our current understanding of proteasome-mediated degradation of ER-associated proteins. A model of hepatic apoB biogenesis is presented.

Original language	English (US)
Pages (from-to)	8-14
Number of pages	7
Journal	Trends in Cardiovascular Medicine
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/S1050-1738(97)00120-5
State	Published - Jan 1998

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S1050-1738(97)00120-5

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title = "Hepatic apolipoprotein B biogenesis: An update",

abstract = "Approximately one half to two thirds of newly synthesized apolipoprotein B (apoB) in Hep G2 cells (a human hepatoma cell line) is degraded. The intracellular degradation of apoB associated with the rough endoplasmic reticulum (ER) is reviewed in the context of our current understanding of proteasome-mediated degradation of ER-associated proteins. A model of hepatic apoB biogenesis is presented.",

author = "Sai-Ching, {Jim Yeung} and Lawrence Chan",

note = "Funding Information: The work performed in the authors' laboratory and reviewed in this article was supported by National Institutes of Health grant HL16512 (to L.C.) and fellowship GM17159 (to S.J.Y.).",

year = "1998",

month = jan,

doi = "10.1016/S1050-1738(97)00120-5",

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T1 - Hepatic apolipoprotein B biogenesis

T2 - An update

AU - Sai-Ching, Jim Yeung

AU - Chan, Lawrence

N1 - Funding Information: The work performed in the authors' laboratory and reviewed in this article was supported by National Institutes of Health grant HL16512 (to L.C.) and fellowship GM17159 (to S.J.Y.).

PY - 1998/1

Y1 - 1998/1

N2 - Approximately one half to two thirds of newly synthesized apolipoprotein B (apoB) in Hep G2 cells (a human hepatoma cell line) is degraded. The intracellular degradation of apoB associated with the rough endoplasmic reticulum (ER) is reviewed in the context of our current understanding of proteasome-mediated degradation of ER-associated proteins. A model of hepatic apoB biogenesis is presented.

AB - Approximately one half to two thirds of newly synthesized apolipoprotein B (apoB) in Hep G2 cells (a human hepatoma cell line) is degraded. The intracellular degradation of apoB associated with the rough endoplasmic reticulum (ER) is reviewed in the context of our current understanding of proteasome-mediated degradation of ER-associated proteins. A model of hepatic apoB biogenesis is presented.

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U2 - 10.1016/S1050-1738(97)00120-5

DO - 10.1016/S1050-1738(97)00120-5

M3 - Review article

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AN - SCOPUS:0345516012

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JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

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ER -

Hepatic apolipoprotein B biogenesis: An update

Abstract

ASJC Scopus subject areas

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