TY - JOUR
T1 - Hepatocellular carcinoma pathogenesis
T2 - From genes to environment
AU - Farazi, Paraskevi A.
AU - DePinho, Ronald A.
N1 - Funding Information:
We would like to thank N. Fausto, G. Merlino, L. Rudolph, E. Sahin, and S. Thorgeirsson for critical reading of this manuscript and helpful suggestions. R.A.D. is an American Cancer Society Research Professor and an Ellison Medical Foundation Senior Scholar. This work is supported by an NIH grant and by the Robert A. and Renee E. Belfer Foundation Institute for Innovative Cancer Science. We apologize to those whose work could not be included owing to space limitations.
PY - 2006/9
Y1 - 2006/9
N2 - Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human population. Despite its significance, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive disease pathogenesis, and there are only limited therapeutic options, many with negligible clinical benefit. This Review summarizes the current state of knowledge of this, the most common and dreaded liver neoplasm, and highlights the principal challenges and scientific opportunities that are relevant to controlling this accelerating global health crisis.
AB - Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human population. Despite its significance, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive disease pathogenesis, and there are only limited therapeutic options, many with negligible clinical benefit. This Review summarizes the current state of knowledge of this, the most common and dreaded liver neoplasm, and highlights the principal challenges and scientific opportunities that are relevant to controlling this accelerating global health crisis.
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U2 - 10.1038/nrc1934
DO - 10.1038/nrc1934
M3 - Review article
C2 - 16929323
AN - SCOPUS:33747830764
SN - 1474-175X
VL - 6
SP - 674
EP - 687
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 9
ER -