TY - JOUR
T1 - Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver
AU - Bishayee, Anupam
AU - Sarkar, Alok
AU - Chatterjee, Malay
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1995/7/7
Y1 - 1995/7/7
N2 - The effect of carrot extract on carbon tetrachloride (CCl4)-induced acute liver damage was evaluated. The increased serum enzyme levels (viz., glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate dehydrogenase, alkaline phosphatase, sorbitol and glutamate dehydrogenase) by CCl4-induction were significantly lowered due to pretreatment with the extract. The extract also decreased the elevated serum bilirubin and urea content due to CCl4 administration. Increased activities of hepatic 5′-nucleotidase, acid phosphatase, acid ribonuclease and decreased levels of succinic dehydrogenase, glucose-6-phosphatase and cytochrome P-450 produced by CCl4 were reversed by the extract in a dose-responsive way. Results of this study revealed that carrot could afford a significant protective action in the alleviation of CCl4-induced hepatocellular injury.
AB - The effect of carrot extract on carbon tetrachloride (CCl4)-induced acute liver damage was evaluated. The increased serum enzyme levels (viz., glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate dehydrogenase, alkaline phosphatase, sorbitol and glutamate dehydrogenase) by CCl4-induction were significantly lowered due to pretreatment with the extract. The extract also decreased the elevated serum bilirubin and urea content due to CCl4 administration. Increased activities of hepatic 5′-nucleotidase, acid phosphatase, acid ribonuclease and decreased levels of succinic dehydrogenase, glucose-6-phosphatase and cytochrome P-450 produced by CCl4 were reversed by the extract in a dose-responsive way. Results of this study revealed that carrot could afford a significant protective action in the alleviation of CCl4-induced hepatocellular injury.
KW - Carbon tetrachloride
KW - Carrot extract
KW - Hepatic damage
KW - Hepatoprotection
KW - Serum and liver enzymes
UR - http://www.scopus.com/inward/record.url?scp=0029033710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029033710&partnerID=8YFLogxK
U2 - 10.1016/0378-8741(95)01254-B
DO - 10.1016/0378-8741(95)01254-B
M3 - Article
C2 - 7500638
AN - SCOPUS:0029033710
SN - 0378-8741
VL - 47
SP - 69
EP - 74
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -