Abstract
We have studied the protective effect of garlic (Allium sativum) on hepatic lipid peroxidation and antioxidant status during buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) in Syrian male hamsters. Enhanced lipid peroxidation in the liver of tumour-bearing animals was accompanied by significant decreases in the activities of glutathione peroxidase (GPx) and glutathione-S-transferase (GST) and a reduction in the glutathione (GSH)) level. Administration of garlic extract significantly lowered lipid peroxidation and enhanced the levels of antioxidants. We speculate that garlic exerts its anticarcinogenic effects by influencing hepatic biotransformation enzymes and antioxidants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 849-851 |
| Number of pages | 3 |
| Journal | Medical Science Research |
| Volume | 26 |
| Issue number | 12 |
| State | Published - 1998 |
| Externally published | Yes |
Keywords
- 7,12-dimethylbenz[a]anthracene
- Antioxidants
- Chemoprevention
- Garlic
- Glutathione
- Lipid peroxidation
- Liver
- Oral cancer
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology