TY - JOUR
T1 - Hepatosplenic and other γδ T-cell lymphomas
AU - Vega, Francisco
AU - Medeiros, L. Jeffrey
AU - Gaulard, Philippe
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/6
Y1 - 2007/6
N2 - The 2005 Society for Hematopathology/European Association for Haematopathology Workshop session 11 was dedicated to hepatosplenic T-cell lymphoma (HSTCL). HSTCL is a rare aggressive type of extranodal lymphoma characterized by hepatosplenomegaly, bone marrow involvement, and peripheral blood cytopenias. HSTCL exhibits a distinctive pattern of infiltration; tumor cells preferentially infiltrate the sinusoids of the splenic red pulp, liver, and bone marrow. The tumor cells have a nonactivated cytotoxic T-cell immunophenotype and frequently carry a recurrent cytogenetic abnormality, isochromosome 7q. Most cases express the γδ T-cell receptor, but cases can have an αβ phenotype and are considered to be a variant of the disease. Although HSTCL is the prototype peripheral T-cell lymphoma expressing the γδ T-cell receptor, non-HSTCL proliferations of γδ T cells can involve other extranodal sites, mainly skin and mucosa. These γδ T-cell lymphomas display marked heterogeneity in clinical and histologic features. In contrast with HSTCL, non-HSTCL γδ T-cell lymphomas frequently have an activated cytotoxic phenotype and most likely are not a single disease entity.
AB - The 2005 Society for Hematopathology/European Association for Haematopathology Workshop session 11 was dedicated to hepatosplenic T-cell lymphoma (HSTCL). HSTCL is a rare aggressive type of extranodal lymphoma characterized by hepatosplenomegaly, bone marrow involvement, and peripheral blood cytopenias. HSTCL exhibits a distinctive pattern of infiltration; tumor cells preferentially infiltrate the sinusoids of the splenic red pulp, liver, and bone marrow. The tumor cells have a nonactivated cytotoxic T-cell immunophenotype and frequently carry a recurrent cytogenetic abnormality, isochromosome 7q. Most cases express the γδ T-cell receptor, but cases can have an αβ phenotype and are considered to be a variant of the disease. Although HSTCL is the prototype peripheral T-cell lymphoma expressing the γδ T-cell receptor, non-HSTCL proliferations of γδ T cells can involve other extranodal sites, mainly skin and mucosa. These γδ T-cell lymphomas display marked heterogeneity in clinical and histologic features. In contrast with HSTCL, non-HSTCL γδ T-cell lymphomas frequently have an activated cytotoxic phenotype and most likely are not a single disease entity.
KW - Hepatosplenic T-cell lymphoma
KW - T-cell neoplasms
KW - WHO classification
KW - Workshop 2005, Houston
KW - γδ T-cell lymphoma
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U2 - 10.1309/LRKX8CE7GVPCR1FT
DO - 10.1309/LRKX8CE7GVPCR1FT
M3 - Article
C2 - 17509984
AN - SCOPUS:34250625241
SN - 0002-9173
VL - 127
SP - 869
EP - 880
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 6
ER -