TY - JOUR
T1 - HeRA
T2 - An atlas of enhancer RNAs across human tissues
AU - Zhang, Zhao
AU - Hong, Wei
AU - Ruan, Hang
AU - Jing, Ying
AU - Li, Shengli
AU - Liu, Yaoming
AU - Wang, Jun
AU - Li, Wenbo
AU - Diao, Lixia
AU - Han, Leng
N1 - Funding Information:
Cancer Prevention Research Institute of Texas (CPRIT) [RR150085, RP190570] to the CPRIT Scholar in Cancer Research (L.H.); Cancer Prevention Research Institute of Texas (CPRIT) [RR160083] to the CPRIT Scholar in Cancer Research (W.L.); National Institutes of Health [R56HL142704, R01HL142704, K01DE026561, R03DE025873, R01DE029014 to J.W., R21GM132778, R01GM136922 to W.L.]; UTHealth Innovation for the Cancer Prevention Research Training Program Postdoctoral Fellowship [Cancer Prevention and Research Institute of Texas grant # RP160015]. Funding for open access charge: CPRIT [RR150085].
Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.
PY - 2021/1/8
Y1 - 2021/1/8
N2 - Enhancer RNA (eRNA) is a type of long non-coding RNA transcribed from DNA enhancer regions. Despite critical roles of eRNA in gene regulation, the expression landscape of eRNAs in normal human tissue remains unexplored. Using numerous samples from the Genotype-Tissue Expression project, we characterized 45 411 detectable eRNAs and identified tens of thousands of associations between eRNAs and traits, including gender, race, and age. We constructed a co-expression network to identify millions of putative eRNA regulators and target genes across different tissues. We further constructed a user-friendly data portal, Human enhancer RNA Atlas (HeRA, https://hanlab.uth.edu/HeRA/). In HeRA, users can search, browse, and download the eRNA expression profile, trait-related eRNAs, and eRNA co-expression network by searching the eRNA ID, gene symbol, and genomic region in one or multiple tissues. HeRA is the first data portal to characterize eRNAs from 9577 samples across 54 human tissues and facilitates functional and mechanistic investigations of eRNAs.
AB - Enhancer RNA (eRNA) is a type of long non-coding RNA transcribed from DNA enhancer regions. Despite critical roles of eRNA in gene regulation, the expression landscape of eRNAs in normal human tissue remains unexplored. Using numerous samples from the Genotype-Tissue Expression project, we characterized 45 411 detectable eRNAs and identified tens of thousands of associations between eRNAs and traits, including gender, race, and age. We constructed a co-expression network to identify millions of putative eRNA regulators and target genes across different tissues. We further constructed a user-friendly data portal, Human enhancer RNA Atlas (HeRA, https://hanlab.uth.edu/HeRA/). In HeRA, users can search, browse, and download the eRNA expression profile, trait-related eRNAs, and eRNA co-expression network by searching the eRNA ID, gene symbol, and genomic region in one or multiple tissues. HeRA is the first data portal to characterize eRNAs from 9577 samples across 54 human tissues and facilitates functional and mechanistic investigations of eRNAs.
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U2 - 10.1093/nar/gkaa940
DO - 10.1093/nar/gkaa940
M3 - Article
C2 - 33119754
AN - SCOPUS:85099429069
SN - 0305-1048
VL - 49
SP - D932-D938
JO - Nucleic acids research
JF - Nucleic acids research
IS - D1
ER -